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Transcription factor SOX-2 Recombinant Protein | SOX2 recombinant protein
Recombinant Human Transcription factor SOX-2
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NCBI and Uniprot Product Information
NCBI Description
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
Uniprot Description
SOX2: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.
Protein type: DNA-binding; Cell development/differentiation; Transcription factor
Chromosomal Location of Human Ortholog: 3q26.3-q27
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin DNA binding; DNA binding; miRNA binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity
Biological Process: adenohypophysis development; alveolus development; cell cycle arrest; cerebral cortex development; detection of mechanical stimulus involved in equilibrioception; detection of mechanical stimulus involved in sensory perception of sound; diencephalon morphogenesis; endodermal cell fate specification; establishment and/or maintenance of chromatin architecture; eye development; forebrain development; forebrain neuron differentiation; glial cell fate commitment; inner ear development; inner ear morphogenesis; male genitalia development; negative regulation of epithelial cell proliferation; negative regulation of neuron differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; neuron fate commitment; olfactory placode formation; osteoblast differentiation; pigment biosynthetic process; pituitary gland development; positive regulation of cell-cell adhesion; positive regulation of epithelial cell differentiation; positive regulation of MAPKKK cascade; positive regulation of neuroblast proliferation; positive regulation of neuron differentiation; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of caspase activity; regulation of gene expression; regulation of transcription, DNA-dependent; response to retinoic acid; response to wounding; retina morphogenesis in camera-type eye; somatic stem cell maintenance; stem cell differentiation; tissue regeneration; tongue development; transcription from RNA polymerase II promoter
Disease: Microphthalmia, Syndromic 3; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Research Articles on SOX2
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Product Notes
The SOX2 sox2 (Catalog #AAA959792) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-317aa; Full Length. The amino acid sequence is listed below: MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM GSVVKSEASS SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS GPVPGTAING TLPLSHM. It is sometimes possible for the material contained within the vial of "Transcription factor SOX-2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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