SDS-PAGE
SOD2 / Mn-SOD recombinant protein
Recombinant Human SOD2 / Mn-SOD Protein
SDS-PAGE
SDS-PAGE
Description: A DNA sequence encoding the mature form of human SOD2 (P04179-1) (Lys 25-Lys 222) was expressed and purified, with an initial Met.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
Uniprot Description
SOD2: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the iron/manganese superoxide dismutase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.15.1.1; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 6q25.3
Cellular Component: mitochondrial matrix; mitochondrion
Molecular Function: identical protein binding; manganese ion binding; superoxide dismutase activity
Biological Process: acetylcholine vasodilation involved in regulation of systemic arterial blood pressure; age-dependent response to reactive oxygen species; negative regulation of cell proliferation; negative regulation of neuron apoptosis; oxygen homeostasis; protein homotetramerization; regulation of blood pressure; regulation of transcription from RNA polymerase II promoter; release of cytochrome c from mitochondria; removal of superoxide radicals; response to reactive oxygen species; response to superoxide; superoxide metabolic process
Disease: Microvascular Complications Of Diabetes, Susceptibility To, 6
Research Articles on SOD2 / Mn-SOD
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Product Notes
The SOD2 / Mn-SOD sod2 (Catalog #AAA2545466) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The recombinant human SOD2 consisting of 199 amino acids and has a calculated molecular mass of 22.3 kDa. It migrates as an 25 kDa band in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the SOD2 / Mn-SOD sod2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SOD2 / Mn-SOD, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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