Alpha-1-syntrophin (SNTA1) Recombinant Protein | SNTA1 recombinant protein

Recombinant Human Alpha-1-syntrophin (SNTA1)

Cat. Num. AAA1379557

• Gene Names: SNTA1; SNT1; LQT12; TACIP1; dJ1187J4.5
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Alpha-1-syntrophin (SNTA1); Recombinant Human Alpha-1-syntrophin (SNTA1); SNTA1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-505, Full length protein
• Sequence: MASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQPSSPGPTPRNFSEAKHMSLKMAYVSKRCTPNDPEPRYLEICSADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLLYLSLPETREALSRPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRPCSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLHSCPKTIVFIIHSFLSAKVTRLGLLA
• Sequence Length: 505

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for SNTA1 recombinant protein

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. This protein is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes.

NCBI and Uniprot Product Information

• NCBI GI #: 4507137
• NCBI GeneID: 6640
• NCBI Accession #: NP_003089.1
• NCBI GenBank Nucleotide #: NM_003098.2
• UniProt Accession #: Q13424; Q16438; A8K7H9; B4DX40; E1P5N1
• Molecular Weight: 45,951 Da
• NCBI Official Full Name: alpha-1-syntrophin
• NCBI Official Synonym Full Names: syntrophin alpha 1
• NCBI Official Symbol: SNTA1
• NCBI Official Synonym Symbols: SNT1; LQT12; TACIP1; dJ1187J4.5
• NCBI Protein Information: alpha-1-syntrophin
• UniProt Protein Name: Alpha-1-syntrophin
• Protein Family: Alpha-1-syntrophin
• UniProt Gene Name: SNTA1
• UniProt Synonym Gene Names: SNT1; TACIP1

NCBI Description

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]

Uniprot Description

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate ().