Rat SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 ELISA Kit | SMARCAL1 elisa kit
Rat SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1, SMARCAL1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SMARCAL1: ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. Defects in SMARCAL1 are a cause of Schimke immuno-osseous dysplasia (SIOD). SIOD causes spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. Approximately half of all patients also exhibit hyperthyroidism, while around half also exhibit episodal cerebral ischema. Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
Protein type: EC 3.6.1.-; EC 3.6.4.-; Helicase
Cellular Component: nucleoplasm; DNA replication factor A complex; nucleus
Molecular Function: DNA-dependent ATPase activity; DNA binding; helicase activity; ATP binding
Biological Process: regulation of transcription from RNA polymerase II promoter; DNA strand renaturation; chromatin modification; DNA repair; response to DNA damage stimulus; DNA metabolic process; replication fork processing
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Product Notes
The Rat SMARCAL1 smarcal1 (Catalog #AAA9340526) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9340526 ELISA Kit recognizes Rat SMARCAL1. It is sometimes possible for the material contained within the vial of "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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