Mouse SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 ELISA Kit | SMARCA4 elisa kit
Mouse Transcription activator BRG1, SMARCA4 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SMARCA4: a member of the SWI/SNF nucleosome remodeling complex with ATP-dependent DNA helicase activity. SWI/SNF complexes are required for mammalian development and are mutated in ~20% of all human primary tumors. Mutated in 35% (13/37) of NSCLC and 5% (1/19) of SCLC human lung cancer cell lines . A component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Belongs to the neural progenitor-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). Component of the BAF53 complex which acetylates histone H4 and H2A within nucleosomes. Transcriptional coactivator of nuclear hormone receptors. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription, and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. SMARCA4, in consort with ZEB1, represses the transcription of E-cadherin and promotes the epithelial-to-mesenchymal transisition (EMT). SMARCA4 is required for stem cell maintenance in the mouse intestinal epithelium. Its loss inhibits aberrant Wnt-signalling and prevents tumorigenesis in the mouse small intestine. SMARCA4 mutations are the cause of a familial cancer syndrome predisposing to renal or extrarenal malignant rhabdoid tumors and to a variety of tumors of the central nervous system, including choroid plexus carcinoma, medulloblastoma, and central primitive neuroectodermal tumors. Rhabdoid tumors are the most aggressive and lethal malignancies occurring in early childhood. Belongs to the SNF2/RAD54 helicase family. The human protein includes 5 isoforms produced by alternative splicing.
Protein type: Tumor suppressor; Transcription, coactivator/corepressor; Nuclear receptor co-regulator; EC 3.6.4.-; Helicase; Cell cycle regulation; EC 3.6.1.-
Cellular Component: heterochromatin; extracellular space; SWI/SNF complex; protein complex; perichromatin fibrils; membrane; nuclear chromatin; nucleolus; nucleus
Molecular Function: DNA-dependent ATPase activity; nucleosomal DNA binding; hydrolase activity; histone binding; p53 binding; transcription coactivator activity; ATPase activity; nucleotide binding; protein N-terminus binding; helicase activity; transcription factor binding; protein binding; hydrolase activity, acting on acid anhydrides; DNA binding; androgen receptor binding; Tat protein binding; protein complex binding; chromatin binding; transcription corepressor activity; ATP binding; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Biological Process: transcription from RNA polymerase II promoter; extracellular matrix organization and biogenesis; glial cell fate determination; positive regulation of transcription, DNA-dependent; heart development; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of cell migration; embryonic hindlimb morphogenesis; embryonic organ morphogenesis; regulation of transcription, DNA-dependent; epidermis morphogenesis; positive regulation of cell proliferation; forebrain development; blastocyst hatching; blastocyst growth; vasculogenesis; positive regulation of Wnt receptor signaling pathway; positive regulation of DNA binding; hindbrain development; blood vessel development; nervous system development; transcription, DNA-dependent; in utero embryonic development; stem cell maintenance; chromatin modification; liver development; keratinocyte differentiation; chromatin remodeling; nucleosome assembly; cytosine methylation within a CG sequence; neurogenesis; methylation-dependent chromatin silencing; nucleosome disassembly; ATP-dependent chromatin remodeling; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; positive regulation of cell differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
Research Articles on SMARCA4
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Product Notes
The Mouse SMARCA4 smarca4 (Catalog #AAA9328378) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328378 ELISA Kit recognizes Mouse SMARCA4. It is sometimes possible for the material contained within the vial of "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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