Very long-chain acyl-CoA synthetase (Slc27a2) Recombinant Protein | Slc27a2 recombinant protein
Recombinant Mouse Very long-chain acyl-CoA synthetase (Slc27a2)
NCBI and Uniprot Product Information
Uniprot Description
SLC27A2: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; EC 6.2.1.3; Membrane protein, multi-pass; Ligase
Cellular Component: peroxisomal membrane; integral to peroxisomal membrane; endoplasmic reticulum membrane; intracellular membrane-bound organelle; mitochondrion; membrane; endoplasmic reticulum lumen; endoplasmic reticulum; integral to membrane; integral to endoplasmic reticulum membrane; peroxisome
Molecular Function: branched-chain acyl-CoA synthetase (ADP-forming) activity; acyl-CoA ligase activity; fatty acid transporter activity; succinate-CoA ligase activity; nucleotide binding; 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity; 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity; very-long-chain-fatty-acid-CoA ligase activity; 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity; phytanate-CoA ligase activity; enzyme binding; fatty-acid ligase activity; benzoyl acetate-CoA ligase activity; 2,4-dichlorobenzoate-CoA ligase activity; aryl-CoA synthetase (ADP-forming) activity; catalytic activity; ATP binding; receptor binding; long-chain-fatty-acid-CoA ligase activity; ligase activity
Biological Process: bile acid biosynthetic process; fatty acid beta-oxidation; very-long-chain fatty acid catabolic process; very-long-chain fatty acid metabolic process; metabolic process; lipid metabolic process; long-chain fatty acid metabolic process; fatty acid metabolic process; fatty acid transport; fatty acid alpha-oxidation
Research Articles on Slc27a2
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Product Notes
The Slc27a2 slc27a2 (Catalog #AAA1128817) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-620. The amino acid sequence is listed below: MLPVLYTGLA GLLLLPLLLT CCCPYLLQDV RYFLRLANMA RRVRSYRQRR PVRTILRAFL EQARKTPHKP FLLFRDETLT YAQVDRRSNQ VARALHDQLG LRQGDCVALF MGNEPAYVWI WLGLLKLGCP MACLNYNIRA KSLLHCFQCC GAKVLLASPD LQEAVEEVLP TLKKDAVSVF YVSRTSNTNG VDTILDKVDG VSAEPTPESW RSEVTFTTPA VYIYTSGTTG LPKAATINHH RLWYGTGLAM SSGITAQDVI YTTMPLYHSA ALMIGLHGCI VVGATLALRS KFSASQFWDD CRKYNVTVIQ YIGELLRYLC NTPQKPNDRD HKVKKALGNG LRGDVWREFI KRFGDIHVYE FYASTEGNIG FVNYPRKIGA VGRANYLQRK VARYELIKYD VEKDEPVRDA NGYCIKVPKG EVGLLVCKIT QLTPFIGYAG GKTQTEKKKL RDVFKKGDIY FNSGDLLMID RENFVYFHDR VGDTFRWKGE NVATTEVADI VGLVDFVEEV NVYGVPVPGH EGRIGMASLK IKENYEFNGK KLFQHIAEYL PSYARPRFLR IQDTIEITGT FKHRKVTLME EGFNPTVIKD TLYFMDDAEK TFVPMTENIY NAIIDKTLKL. It is sometimes possible for the material contained within the vial of "Very long-chain acyl-CoA synthetase (Slc27a2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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