Sirpa recombinant protein

Recombinant Mouse Sirpa protein, Fc Tag

Cat. Num. AAA157119

• Gene Names: Sirpa; Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; AI835480
• Purity: >90% as determined by SDS-PAGE
• Synonyms: Sirpa; Recombinant Mouse Sirpa protein; Fc Tag; SHP substrate 1; CD172 antigen-like family member A; inhibitory receptor SHPS-1; MyD-1 antigen; Sirp-alpha-1; mSIRP-alpha1; CD172a; p84; Sirpa recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose?1mM EDTA

• Source: Mouse
• Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
• Construction: A DNA sequence encoding the MouseSirpa (Lys32-Leu146) was fused with the Fc Tag
• Preparation and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for ~12 months from the date of receipt.; Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise

Product Categories/Family for Sirpa recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 294997315
• NCBI GeneID: 19261
• NCBI Accession #: NP_001171117.1
• NCBI GenBank Nucleotide #: NM_001177646.1
• UniProt Accession #: P97797; O08907; O35924; O88555; O88556; P97796; Q8R559; Q9QX57; Q9WTN4
• Molecular Weight: 56,425 Da
• NCBI Official Full Name: tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1
• NCBI Official Synonym Full Names: signal-regulatory protein alpha
• NCBI Official Symbol: Sirpa
• NCBI Official Synonym Symbols: Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; AI835480
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type substrate 1; mSIRP-alpha1; sirp-alpha-1; myD-1 antigen; SHP substrate 1; inhibitory receptor SHPS-1; signal-regulatory protein alpha-1; CD172 antigen-like family member A; brain immunological-like with tyrosi
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type substrate 1
• Protein Family: Tyrosine-protein phosphatase non-receptor
• UniProt Gene Name: Sirpa
• UniProt Synonym Gene Names: Bit; Myd1; Ptpns1; Shps1; Sirp; SHP substrate 1; SHPS-1; Bit; Sirp-alpha-1
• UniProt Entry Name: SHPS1_MOUSE

Uniprot Description

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells ().