SIGLEC10 recombinant protein

Recombinant Human SIGLEC10 protein with C-terminal 6xHis tag

Cat. Num. AAA188127

• Gene Names: SIGLEC10; SLG2; PRO940; SIGLEC-10
• Applications: Western Blot
• Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
• Synonyms: SIGLEC10; Recombinant Human SIGLEC10 protein with C-terminal 6xHis tag; Human SIGLEC10 Protein; His Tag; Siglec-10; SLG2; PRO940; MGC126774; SIGLEC10 recombinant protein

• Host: HEK293 cells
• Purity/Purification: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
• Form/Format: Lyophilized from sterile PBS, pH 7.4. Normally 5%-76% trehalose is added as protectants before lyophilization.
• Sequence: SIGLEC10(Met17-Thr546)

• Applicable Applications for SIGLEC10 recombinant protein: Western Blot (WB)
• Source: Human
• Conjugation: C-6xHis tag
• Reconstitution: Reconstitute with deionized water
• Preparation and Storage: Store at -80 degree C for 12 months (Avoid repeated freezing and thawing); Shipping: Blue Ice

SDS-Page

(Figure 1. Human SIGLEC10 Protein, His Tag on SDS-PAGE under reducing condition.)

Related Product Information for SIGLEC10 recombinant protein

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).

NCBI and Uniprot Product Information

• NCBI GI #: 283837876
• NCBI GeneID: 89790
• NCBI Accession #: NP_001164627.1
• NCBI GenBank Nucleotide #: NP_001164627.1
• UniProt Accession #: Q96LC7
• NCBI Official Full Name: sialic acid-binding Ig-like lectin 10 isoform 2
• NCBI Official Synonym Full Names: sialic acid binding Ig like lectin 10
• NCBI Official Symbol: SIGLEC10
• NCBI Official Synonym Symbols: SLG2; PRO940; SIGLEC-10
• NCBI Protein Information: sialic acid-binding Ig-like lectin 10
• UniProt Protein Name: Sialic acid-binding Ig-like lectin 10
• Protein Family: Sialic acid-binding Ig-like lectin
• UniProt Gene Name: SIGLEC10
• UniProt Synonym Gene Names: SLG2; Siglec-10
• UniProt Entry Name: SIG10_HUMAN

NCBI Description

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

Uniprot Description

Siglec-10: a cell surface protein belonging to the immunoglobulin superfamily and the SIGLEC (sialic acid binding Ig-like lectin) family. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Five alternatively spliced isoforms have been described.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: plasma membrane; integral to membrane; extracellular region

Molecular Function: carbohydrate binding

Biological Process: cell adhesion