Rabbit anti-Human Siglec 10 Polyclonal Antibody | anti-SIGLEC10 antibody

Siglec 10, CT (Siglec 10, SLG2, Sialic acid-binding Ig-like lectin 10, Siglec like protein 2) (PE)

Cat. Num. AAA6347592

• Gene Names: SIGLEC10; SLG2; PRO940; SIGLEC-10
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: Siglec 10; Polyclonal Antibody; CT (Siglec 10; SLG2; Sialic acid-binding Ig-like lectin 10; Siglec like protein 2) (PE); SIGLEC10; Siglec-like protein 2; anti-SIGLEC10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SIGLEC10.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
• Sequence Length: 602

• Applicable Applications for anti-SIGLEC10 antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 667-695 in the C-terminal region of human SIGLEC10.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in MCF-7 cell line lysates (35ug/lane) usingMBS6011682. This demonstrates the MBS6011682 detected the SIGLEC10 protein (arrow).)

Related Product Information for anti-SIGLEC10 antibody

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).

Product Categories/Family for anti-SIGLEC10 antibody

Antibodies; Lectins

References

1. Davila, S., et al. Genes Immun. 11(3):232-238(2010). 2. Kivi, E., et al. Blood 114(26):5385-5392(2009). 3. Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007). 4. Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003). 5. Kitzig, F., et al. Biochem. Biophys. Res. Commun. 296(2):355-362(2002).

NCBI and Uniprot Product Information

• NCBI GI #: 283837878
• NCBI GeneID: 89790
• NCBI Accession #: NP_001164628.1; NP_001164627.1
• NCBI GenBank Nucleotide #: NP_001164628.1
• UniProt Accession #: Q96LC7
• NCBI Official Full Name: sialic acid-binding Ig-like lectin 10 isoform 3
• NCBI Official Synonym Full Names: sialic acid binding Ig like lectin 10
• NCBI Official Symbol: SIGLEC10
• NCBI Official Synonym Symbols: SLG2; PRO940; SIGLEC-10
• NCBI Protein Information: sialic acid-binding Ig-like lectin 10
• UniProt Protein Name: Sialic acid-binding Ig-like lectin 10
• Protein Family: Sialic acid-binding Ig-like lectin
• UniProt Gene Name: SIGLEC10
• UniProt Synonym Gene Names: SLG2; Siglec-10
• UniProt Entry Name: SIG10_HUMAN

NCBI Description

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

Uniprot Description

Siglec-10: a cell surface protein belonging to the immunoglobulin superfamily and the SIGLEC (sialic acid binding Ig-like lectin) family. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Five alternatively spliced isoforms have been described.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: plasma membrane; integral to membrane; extracellular region

Molecular Function: carbohydrate binding

Biological Process: cell adhesion