Sialic acid-binding Ig-like lectin 10 (SIGLEC10) Recombinant Protein | SIGLEC10 recombinant protein

Recombinant Human Sialic acid-binding Ig-like lectin 10 (SIGLEC10), partial

Cat. Num. AAA1471491

• Gene Names: SIGLEC10; SLG2; PRO940; SIGLEC-10
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Sialic acid-binding Ig-like lectin 10 (SIGLEC10); Recombinant Human Sialic acid-binding Ig-like lectin 10 (SIGLEC10); partial; SIGLEC10 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 17-550
• Sequence: MDGR FWIRVQESVM VPEGLCISVP CSFSYPRQDW TGSTPAYGYW FKAVTETTKG APVATNHQSR EVEMSTRGRF QLTGDPAKGN CSLVIRDAQM QDESQYFFRV ERGSYVRYNF MNDGFFLKVT ALTQKPDVYI PETLEPGQPV TVICVFNWAF EECPPPSFSW TGAALSSQGT KPTTSHFSVL SFTPRPQDHN TDLTCHVDFS RKGVSAQRTV RLRVAYAPRD LVISISRDNT PALEPQPQGN VPYLEAQKGQ FLRLLCAADS QPPATLSWVL QNRVLSSSHP WGPRPLGLEL PGVKAGDSGR YTCRAENRLG SQQRALDLSV QYPPENLRVM VSQANRTVLE NLGNGTSLPV LEGQSLCLVC VTHSSPPARL SWTQRGQVLS PSQPSDPGVL ELPRVQVEHE GEFTCHARHP LGSQHVSLSL SVHYSPKLLG PSCSWEAEGL HCSCSSQASP APSLRWWLGE ELLEGNSSQD SFEVTPSSAG PWANSSLSLH GGLSSGLRLR CEAWNVHGAQ SGSILQLPDK KGLISTAFSN
• Sequence Length: 534

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 283837876
• NCBI GeneID: 89790
• NCBI Accession #: NP_001164627.1
• NCBI GenBank Nucleotide #: NM_001171156.1
• UniProt Accession #: Q96LC7; Q3MIR5; Q6UXI8; Q96G54; Q96LC8; A8K1I5; A8K3C7; C9JJ33; C9JM10; F8W917
• Molecular Weight: 57,486 Da
• NCBI Official Full Name: sialic acid-binding Ig-like lectin 10 isoform 2
• NCBI Official Synonym Full Names: sialic acid binding Ig like lectin 10
• NCBI Official Symbol: SIGLEC10
• NCBI Official Synonym Symbols: SLG2; PRO940; SIGLEC-10
• NCBI Protein Information: sialic acid-binding Ig-like lectin 10
• UniProt Protein Name: Sialic acid-binding Ig-like lectin 10
• Protein Family: Sialic acid-binding Ig-like lectin
• UniProt Gene Name: SIGLEC10
• UniProt Synonym Gene Names: SLG2; Siglec-10

NCBI Description

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

Uniprot Description

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (). During initiation of adaptive immune responses by CD8-alpha+ dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification ().