Sheep Claudin-18 (CLDN18) ELISA Kit | CLDN18 elisa kit
Sheep Claudin-18 (CLDN18) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
Uniprot Description
Claudin-18: a multi-pass membrane protein with calcium-independent cell-adhesion activity that plays a major role in the formation of tight junctions. Belongs to the claudin family. Two isoforms of the human protein are produced by alternative splicing. Isoform 2 is a specific cell lineage marker. Its expression in normal tissues is restricted to differentiated epithelial cells of the gastric mucosa; it is absent from the gastric stem cells. Isoform 2 is expressed in a significant proportion of primary gastric cancers and metastases, as well as in subtypes of pancreatic, esophageal, ovarian, and lung tumors.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 3q22.3
Cellular Component: tight junction; plasma membrane; integral to membrane
Molecular Function: identical protein binding; structural molecule activity
Biological Process: intercellular junction assembly and maintenance; calcium-independent cell-cell adhesion
Research Articles on CLDN18
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Product Notes
The Sheep CLDN18 cldn18 (Catalog #AAA7205804) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7205804 ELISA Kit recognizes Sheep CLDN18. It is sometimes possible for the material contained within the vial of "Claudin-18 (CLDN18), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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