Rabbit TCEB2 Polyclonal Antibody | anti-TCEB2 antibody

TCEB2 Rabbit Polyclonal

Cat. Num. AAA7604782

• Gene Names: TCEB2; ELOB; SIII
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: TCEB2; Polyclonal Antibody; TCEB2 Rabbit Polyclonal; anti-TCEB2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 161

• Applicable Applications for anti-TCEB2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon cancer using MBS7604782 (TCEB2 antibody) at dilution of 1:100)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7604782 (TCEB2 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 46276893
• NCBI GeneID: 6923
• NCBI Accession #: NP_996896.1
• NCBI GenBank Nucleotide #: NM_207013.2
• Molecular Weight: 17,911 Da
• NCBI Official Full Name: transcription elongation factor B polypeptide 2 isoform b
• NCBI Official Synonym Full Names: transcription elongation factor B subunit 2
• NCBI Official Symbol: TCEB2
• NCBI Official Synonym Symbols: ELOB; SIII
• NCBI Protein Information: transcription elongation factor B polypeptide 2
• UniProt Protein Name: Transcription elongation factor B polypeptide 2
• Protein Family: Transcription elongation factor B polypeptide
• UniProt Gene Name: TCEB2
• UniProt Synonym Gene Names: EloB
• UniProt Entry Name: ELOB_HUMAN

NCBI Description

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

Uniprot Description

TCEB2: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Chromosomal Location of Human Ortholog: 16p12.3

Cellular Component: Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex; cytosol; nucleoplasm; VCB complex

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: protein complex assembly; protein ubiquitination; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter