SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) Recombinant Protein | SHANK2 recombinant protein

Recombinant Human SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) , partial

• Gene Names: SHANK2; SHANK; AUTS17; CORTBP1; CTTNBP1; ProSAP1; SPANK-3
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: SH3 and multiple ankyrin repeat domains protein 2 (SHANK2); Recombinant Human SH3 and multiple ankyrin repeat domains protein 2 (SHANK2); partial; SHANK2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,254

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for SHANK2 recombinant protein

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95
Dlg
ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 226817313
• NCBI GeneID: 22941
• NCBI Accession #: NP_036441.2
• NCBI GenBank Nucleotide #: NM_012309.4
• UniProt Accession #: Q9UPX8; Q3Y8G9; Q52LK2; Q9UKP1; C0SPG8; C0SPG9
• Molecular Weight: 134,931 Da
• NCBI Official Full Name: SH3 and multiple ankyrin repeat domains protein 2 isoform 1
• NCBI Official Synonym Full Names: SH3 and multiple ankyrin repeat domains 2
• NCBI Official Symbol: SHANK2
• NCBI Official Synonym Symbols: SHANK; AUTS17; CORTBP1; CTTNBP1; ProSAP1; SPANK-3
• NCBI Protein Information: SH3 and multiple ankyrin repeat domains protein 2
• UniProt Protein Name: SH3 and multiple ankyrin repeat domains protein 2
• Protein Family: SH3 and multiple ankyrin repeat domains protein
• UniProt Gene Name: SHANK2
• UniProt Synonym Gene Names: CORTBP1; KIAA1022; PROSAP1; Shank2; CortBP1

NCBI Description

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Description

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.