Human SH3 and PX domains 2B ELISA Kit | SH3PXD2B elisa kit

Human SH3 and PX domain-containing protein 2B, SH3PXD2B ELISA Kit

Cat. Num. AAA9334398

• Gene Names: SH3PXD2B; FTHS; HOFI; TKS4; TSK4; FAD49; KIAA1295
• Reactivity: Human
• Synonyms: SH3 and PX domains 2B; Human SH3 and PX domain-containing protein 2B; SH3PXD2B ELISA Kit; Human SH3 and PX domain-containing protein 2B (SH3PXD2B) ELISA kit; FAD49; FLJ20831; HOFI; KIAA1295; adaptor protein HOFI; SH3PXD2B elisa kit

• Reactivity: Human

• Assay Type: Quantitative Sandwich
• Detection Range: 6.25ng/ml-200ng/ml
• Sensitivity: 1.0ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for SH3PXD2B elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of SH3PXD2B (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 63055059
• NCBI GeneID: 285590
• NCBI Accession #: NP_001017995.1
• NCBI GenBank Nucleotide #: NM_001017995.2
• UniProt Accession #: A1X283; Q9P2Q1; B6F0V2
• Molecular Weight: 101,579 Da
• NCBI Official Full Name: SH3 and PX domain-containing protein 2B
• NCBI Official Synonym Full Names: SH3 and PX domains 2B
• NCBI Official Symbol: SH3PXD2B
• NCBI Official Synonym Symbols: FTHS; HOFI; TKS4; TSK4; FAD49; KIAA1295
• NCBI Protein Information: SH3 and PX domain-containing protein 2B; adapter protein HOFI; adaptor protein HOFI; factor for adipocyte differentiation 49; tyrosine kinase substrate with four SH3 domains
• UniProt Protein Name: SH3 and PX domain-containing protein 2B
• Protein Family: SH3 and PX domain-containing protein
• UniProt Gene Name: SH3PXD2B
• UniProt Synonym Gene Names: FAD49; KIAA1295; TKS4
• UniProt Entry Name: SPD2B_HUMAN

NCBI Description

This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome. [provided by RefSeq, Sep 2010]

Uniprot Description

SH3PXD2B: Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation. Defects in SH3PXD2B are the cause of Frank-Ter Haar syndrome (FTHS). It is a syndrome characterized by brachycephaly, wide fontanels, prominent forehead, hypertelorism, prominent eyes, macrocornea with or without glaucoma, full cheeks, small chin, bowing of the long bones and flexion deformity of the fingers. Belongs to the SH3PXD2 family.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: cell projection; cytoplasm; podosome; cell junction

Molecular Function: protein binding; phosphatidylinositol-5-phosphate binding; SH2 domain binding; phosphatidylinositol 3-phosphate binding

Biological Process: extracellular matrix disassembly; eye development; heart development; superoxide metabolic process; positive regulation of fat cell differentiation; cell differentiation; skeletal development

Disease: Frank-ter Haar Syndrome