SH3 Domain Binding Protein 2 (SH3BP2) Recombinant Protein | SH3BP2 recombinant protein

Recombinant SH3 Domain Binding Protein 2 (SH3BP2)

Cat. Num. AAA2086937

• Gene Names: SH3BP2; 3BP2; CRBM; CRPM; 3BP-2; RES4-23
• Applications: SDS-Page, Western Blot
• Purity: >90%
• Synonyms: SH3 Domain Binding Protein 2 (SH3BP2); Recombinant SH3 Domain Binding Protein 2 (SH3BP2); CRBM; RES4-23; Cherubism; SH3BP2 recombinant protein

• Host: E Coli
• Purity/Purification: >90%
• Form/Format: Freeze-dried powder
• Sequence Length: 561

• Applicable Applications for SH3BP2 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Fragment: Met1~Leu259
• Tag: N-terminal His-tag
• Buffer Formulation: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Source Note: Prokaryotic expression
• Organism Species: Human
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Isoelectric Point: 6.1
• Usage: Reconstitute in sterile ddH2O.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

Product Categories/Family for SH3BP2 recombinant protein

Recombinant Protein

NCBI and Uniprot Product Information

• NCBI GI #: 170014705
• NCBI GeneID: 6452
• NCBI Accession #: NP_001116153.1
• NCBI GenBank Nucleotide #: NM_001122681.1
• UniProt Accession #: P78314; O00500; O15373; P78315; A6NNC2; B2R5R6; B4DT04; D3DVR0; D6R919
• Molecular Weight: 32.6kDa
• NCBI Official Full Name: SH3 domain-binding protein 2 isoform a
• NCBI Official Synonym Full Names: SH3 domain binding protein 2
• NCBI Official Symbol: SH3BP2
• NCBI Official Synonym Symbols: 3BP2; CRBM; CRPM; 3BP-2; RES4-23
• NCBI Protein Information: SH3 domain-binding protein 2
• UniProt Protein Name: SH3 domain-binding protein 2
• Protein Family: SH3 domain-binding protein
• UniProt Gene Name: SH3BP2
• UniProt Synonym Gene Names: 3BP2; 3BP-2

NCBI Description

The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Description

SH3BP2: an adaptor protein that binds differentially to the SH3 domains of certain proteins. Links the hemopoietic tyrosine kinase Fes to the cytoplasmic membrane in a phosphorylation dependent manner. Regulates FC-epsilon RI -mediated degranulation in rat basophilic leukemia RBL-2H3 cells. Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas. Defects in 3BP2 are the cause of cherubism, an autosomal dominant inherited syndrome. Two differentially spliced isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4p16.3

Molecular Function: protein binding; SH3/SH2 adaptor activity

Biological Process: signal transduction

Disease: Cherubism