Specific Activity
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METTL16 Active Protein
METTL16, Active
Synonyms
METTL16; Active; METT10D; MGC3329; METTL16 active protein
Host
Sf9 insect cells
Form/Format
50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol
Species
Human
Tag
GST
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Specific Activity
(Sample Activity Plot.)
Specific Activity
(Sample Activity Plot.)
Purity Data
(Sample Purity Data.)
Purity Data
(Sample Purity Data.)
Related Product Information for METTL16 active protein
Recombinant full-length human METTL16 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Overview: METTL16 (Methyltransferase-like protein 16) is an RNA N6-methyltransferase that methylates adenosine residues at the N6 position of a subset of RNAs. METTL16 methylates the 3' UTR of the SAM synthetase (MAT2A) mRNA and U6 snRNA (1,2), thereby regulating S-adenosylmethionine homeostasis as well as pre-mRNA splicing. These modifications on viral RNAs are believed to influence the expression of viral genes, the replication of virus and the generation of progeny virions (3).
Overview: METTL16 (Methyltransferase-like protein 16) is an RNA N6-methyltransferase that methylates adenosine residues at the N6 position of a subset of RNAs. METTL16 methylates the 3' UTR of the SAM synthetase (MAT2A) mRNA and U6 snRNA (1,2), thereby regulating S-adenosylmethionine homeostasis as well as pre-mRNA splicing. These modifications on viral RNAs are believed to influence the expression of viral genes, the replication of virus and the generation of progeny virions (3).
Product Categories/Family for METTL16 active protein
References
1. Shima, H. et al: S-Adenosylmethionine synthesis is regulated by selective N(6)-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1. Cell Rep. 2017,21:3354-3363.
2. Warda, AS. et al: Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. EMBO Rep. 2017,18:2004-2014.
3. Dang, W. et al: N6-methyladenosine and viral infection. Front. Microbiol. 2019,10:417.
2. Warda, AS. et al: Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. EMBO Rep. 2017,18:2004-2014.
3. Dang, W. et al: N6-methyladenosine and viral infection. Front. Microbiol. 2019,10:417.
NCBI and Uniprot Product Information
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
~98kDa
Protein Family
Similar Products
Product Notes
The METTL16 (Catalog #AAA515778) is an Active Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "METTL16, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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