Testing Data
(specific activity)
Fibroblast Activation Protein Active Protein
Fibroblast Activation Protein, Recombinant, Human (FAP)
~70%
~70%
Testing Data
(specific activity)
Testing Data
(specific activity)
SDS-Page
(10% SDS-PAGE Coomassie staining using 5ug of F4208-50H in lane 1. Lane 2: Protein Marker)
SDS-Page
(10% SDS-PAGE Coomassie staining using 5ug of F4208-50H in lane 1. Lane 2: Protein Marker)
Fibroblast Activation Protein (FAP) is a cell surface glycoprotein of reactive human fibroblasts. Among the normal adult organs tested, F4208-50H does not show immunoreactivity in immunohistological studies with either resting fibroblasts (fibrocytes) of the normal origin mesenchyme or the parenchymal cells. The single exception noted is a subset of endocrine cells in the pancreatic islets, presumably glucagon-producing A cells.
NCBI and Uniprot Product Information
Uniprot Description
FAP: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.21.26; Membrane protein, integral; EC 3.4.14.5; Protease
Chromosomal Location of Human Ortholog: 2q23
Cellular Component: extracellular space; focal adhesion; cell surface; lamellipodium; apical part of cell; cytoplasm; integral to membrane; plasma membrane
Molecular Function: peptidase activity; integrin binding; protein dimerization activity; protein binding; protein homodimerization activity; protease binding; serine-type peptidase activity; dipeptidyl-peptidase activity; metalloendopeptidase activity; serine-type endopeptidase activity; endopeptidase activity
Biological Process: proteolysis involved in cellular protein catabolic process; endothelial cell migration; angiogenesis; proteolysis; cell adhesion; regulation of fibrinolysis
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Product Notes
The Fibroblast Activation Protein (Catalog #AAA636509) is an Active Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. Suitable for use in the study of enzyme kinetics, screening inhibitors and selectivity profiling. Researchers should empirically determine the suitability of the Fibroblast Activation Protein for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fibroblast Activation Protein, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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