Serpin H1 Recombinant Protein | SERPH recombinant protein

Recombinant Mouse Serpin H1

Gene Names

Serpinh1; J6; Cbp1; Cbp2; gp46; Hsp47; BERF-1; Serpinh2

Reactivity

Mouse

Purity

Greater than 90% as determined by SDS-PAGE.

Synonyms

Serpin H1; Recombinant Mouse Serpin H1; SERPH recombinant protein

Ordering
Cat. Num. AAA9420666 For Research Use Only!

Host

E Coli

Reactivity

Mouse

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Form/Format

20mM Tris-HCl based buffer, pH8.0

Sequence Positions

Full Length, 18-417aa

Tag Info

His-SUMO-tag

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

NCBI and Uniprot Product Information

NCBI GI #

161353504

NCBI GeneID

12406

NCBI Accession #

NP_001104513.1

NCBI GenBank Nucleotide #

NM_001111043.1

UniProt Accession #

P19324; Q5U4D0

Molecular Weight

60.77kD

NCBI Official Full Name

serpin H1

NCBI Official Synonym Full Names

serine (or cysteine) peptidase inhibitor, clade H, member 1

NCBI Official Symbol

Serpinh1

NCBI Official Synonym Symbols

J6; Cbp1; Cbp2; gp46; Hsp47; BERF-1; Serpinh2

NCBI Protein Information

serpin H1

UniProt Protein Name

Serpin H1

Protein Family

Serpin

UniProt Gene Name

Serpinh1

UniProt Synonym Gene Names

Cbp1; Hsp47; Colligin

Uniprot Description

SERPINH1: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. Defects in SERPINH1 are the cause of osteogenesis imperfecta type 10 (OI10). A connective tissue disorder characterized by bone fragility, low bone mass, bowing of limbs due to multiple fractures, short limb dwarfism and blue sclerae. Belongs to the serpin family.

Chromosomal Location of Human Ortholog: 7|7 E1

Cellular Component: cytoplasm; endoplasmic reticulum; ER-Golgi intermediate compartment; lipid raft

Molecular Function: collagen binding; protein binding; RNA binding; serine-type endopeptidase inhibitor activity; unfolded protein binding

Biological Process: collagen biosynthetic process; collagen fibril organization; protein maturation

Research Articles on SERPH

1. HSP47 appears after a period of certain activities to repair damaged collagen fibers, and the activity was returned to a state of equilibrium at day 30 with significantly diminished expression. Thus, the results suggest that HSP47 is actively involved in homeostasis of periodontal tissue subjected to occlusal overload

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Product Notes

The SERPH serpinh1 (Catalog #AAA9420666) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Full Length, 18-417aa. The Recombinant Mouse Serpin H1 reacts with Mouse and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Serpin H1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.