Serpin G1/C1 Recombinant Protein | Serping1 recombinant protein

Recombinant Mouse Serpin G1/C1 Inhibitor Protein (C-6His)

Cat. Num. AAA2553611

• Gene Names: Serping1; C1nh; C1INH
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Serpin G1/C1; Recombinant Mouse Serpin G1/C1 Inhibitor Protein (C-6His); SERPIN G1; Plasma protease C1 inhibitor; C1 Inh; C1 esterase inhibitor; C1-inhibiting factor; Serping1; C1nh; Serping1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM Tris HCl, 150mM NaCl, pH 8.0.
• Sequence Positions: Ala20-Gly504
• Sequence Length: 504

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for Serping1 recombinant protein

SERPIN G1 is a member of the serpin family, The C-terminal serpin domain is similar to other serpins, and this part of C1-INH provides the inhibitory activity. SERPIN G1 is involved in the inhibition of the complement system to prevent spontaneous activation. SERPIN G1 may play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. SERPIN G1 prevents the proteolytic cleavage of later complement components C4 and C2 by C1 and MBL. SERPIN G1 is a very efficient physiological inhibitor of FXIIa, plasma kallikrein and fXIa, and could inhibit chymotrypsin and kallikrein. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases in the C1 complex of classical pathway of complement. Activation of the C1 complex is under control of the C1-inhibitor.

NCBI and Uniprot Product Information

• NCBI GI #: 163914390
• NCBI GeneID: 12258
• NCBI Accession #: NP_033906.2
• NCBI GenBank Nucleotide #: NM_009776.3
• UniProt Accession #: P97290; O88330; Q99M43; Q9QX09; A2ATR7
• Molecular Weight: Molecular Mass: 54.6 kDa; Actual Protein Molecular Mass: 90 kDa
• NCBI Official Full Name: plasma protease C1 inhibitor
• NCBI Official Synonym Full Names: serine (or cysteine) peptidase inhibitor, clade G, member 1
• NCBI Official Symbol: Serping1
• NCBI Official Synonym Symbols: C1nh; C1INH
• NCBI Protein Information: plasma protease C1 inhibitor
• UniProt Protein Name: Plasma protease C1 inhibitor
• Protein Family: Plasma protease C1 inhibitor
• UniProt Gene Name: Serping1
• UniProt Synonym Gene Names: C1nh; C1 Inh; C1Inh

Uniprot Description

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein.