Semaphorin-6D (Sema6d) Recombinant Protein | Sema6d recombinant protein

Recombinant Mouse Semaphorin-6D (Sema6d), partial

Cat. Num. AAA1310502

• Gene Names: Sema6d; AA409156; mKIAA1479; D330011G23; 1110067B02Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Semaphorin-6D (Sema6d); Recombinant Mouse Semaphorin-6D (Sema6d); partial; Sema6d recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 21-662
• Sequence: VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ LMLKIRDTLY IAGRDQVYTV NLNEIPQTEV IPSKKLTWRS RQQDRENCAM KGKHKDECHN FIKVFVPRND EMVFVCGTNA FNPMCRYYRL RTLEYDGEEI SGLARCPFDA RQTNVALFAD GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP DSVWTAVPED KVPKPRPGCC AKHGLAEAYK TSIDFPDDTL AFIKSHPLMD SAVPPIADEP WFTKTRVRYR LTAIEVDRSA GPYQNYTVIF VGSEAGVVLK VLAKTSPFSL NDSVLLEEIE AYNPAKCSAE SEEDRKVVSL QLDKDHHALY VAFSSCVVRI PLSRCERYGS CKKSCIASRD PYCGWLSQGV CERVTLGMLP GGYEQDTEYG NTAHLGDCHE SLPPSTTPDY KIFGGPTSDM EVSSSSVTTV ASSPEITSKV IDTWRPKLTS SRKFVVQDDP NTSDFTDTIS GIPKGVRWEV QSGESNQMVH MN
• Sequence Length: 642

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Sema6d recombinant protein

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Six transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.

NCBI and Uniprot Product Information

• NCBI GI #: 597436951
• NCBI GeneID: 214968
• NCBI Accession #: NP_001277926.1
• NCBI GenBank Nucleotide #: NM_001290997.1
• UniProt Accession #: Q76KF0; Q76KF1; Q76KF2; Q76KF3; Q76KF4; Q80TD0; A2AW72
• Molecular Weight: 117,839 Da
• NCBI Official Full Name: semaphorin-6D isoform Sema6D-2
• NCBI Official Synonym Full Names: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
• NCBI Official Symbol: Sema6d
• NCBI Official Synonym Symbols: AA409156; mKIAA1479; D330011G23; 1110067B02Rik
• NCBI Protein Information: semaphorin-6D
• UniProt Protein Name: Semaphorin-6D
• Protein Family: Semaphorin
• UniProt Gene Name: Sema6d
• UniProt Synonym Gene Names: Kiaa1479

Uniprot Description

Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections ().