Rabbit SEMA6D Polyclonal Antibody | anti-SEMA6D antibody

SEMA6D Polyclonal Antibody

Cat. Num. AAA2522444

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: SEMA6D; Polyclonal Antibody; SEMA6D Polyclonal Antibody; anti-SEMA6D antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.6mg/mL (varies by lot)
• Sequence Length: 1011

• Applicable Applications for anti-SEMA6D antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human SEMA6D
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using SEMA6D Polyclonal Antibody at dilution 1:25)

Related Product Information for anti-SEMA6D antibody

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies.

Product Categories/Family for anti-SEMA6D antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 312222667
• NCBI GeneID: 80031
• NCBI Accession #: NP_001185928.1
• NCBI GenBank Nucleotide #: NM_001198999.1
• Molecular Weight: 67,538 Da
• NCBI Official Full Name: semaphorin-6D isoform 1
• NCBI Official Synonym Full Names: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
• NCBI Official Symbol: SEMA6D
• NCBI Protein Information: semaphorin-6D
• UniProt Protein Name: Semaphorin-6D
• Protein Family: Semaphorin
• UniProt Gene Name: SEMA6D
• UniProt Synonym Gene Names: KIAA1479
• UniProt Entry Name: SEM6D_HUMAN

NCBI Description

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]

Uniprot Description

SEMA6D: a single-pass type I membrane protein of the semaphorin family that shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Seven alternatively spliced human isoforms have been reported. All are intrinsic membrane proteins except isoform 7, which is cytoplasmic.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Molecular Function: receptor activity; semaphorin receptor binding

Biological Process: axon guidance; ventricular system development; negative regulation of smooth muscle cell migration; positive regulation of smooth muscle cell migration