Typical Testing Data/Standard Curve (for reference only)
Human Selenoprotein S ELISA Kit | SELS elisa kit
Human Selenoprotein S ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the selenoprotein family, characterized by a selenocysteine (Sec) residue at the active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Uniprot Description
SELS: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. Belongs to the selenoprotein S family.
Protein type: Membrane protein, integral; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component: cytoplasmic microtubule; endoplasmic reticulum; integral to endoplasmic reticulum membrane; plasma membrane
Molecular Function: antioxidant activity; ATPase binding; enzyme binding; protein binding; receptor activity
Biological Process: cell redox homeostasis; cellular response to insulin stimulus; ER overload response; ER-associated protein catabolic process; establishment of protein localization; negative regulation of acute inflammatory response to antigenic stimulus; negative regulation of glucose import; negative regulation of glycogen biosynthetic process; negative regulation of inflammatory response; negative regulation of interleukin-6 production; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of tumor necrosis factor production; regulation of gluconeogenesis; response to glucose stimulus; response to redox state; retrograde protein transport, ER to cytosol; unfolded protein response
Research Articles on SELS
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Product Notes
The Human SELS vimp (Catalog #AAA289082) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA289082 ELISA Kit recognizes Human SELS. It is sometimes possible for the material contained within the vial of "Selenoprotein S, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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