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69 results for "Bcr Abl inhibitor" - showing 1-50
Testing Data
(Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor. It act by specifically inhibiting a certain enzyme that is characteristic of a particular cancer cell, rather than non-specifically inhibiting and killing all rapidly dividing cells, and served as a model for other targeted therapy modalities through tyrosine kinase inhibition. In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion protein of abl with bcr (breakpoint cluster region), termed bcr-abl. As this is now a constitutively active tyrosine kinase, it is used to decrease bcr-abl activity. It is being used as an experimental agent to suppress platelet-derived growth factor (PDGF) by inhibiting its receptor (PDGF-Rbeta).)
Imatinib, Inhibitor (Cat# AAA8506365)
Full Name
Imatinib (Gleevec)
Pricing
$295/250 mg | $1,255/5x250 mg
Western Blot (WB)
(Western blot analysis of extracts from cells expressing various activated tyrosine kinase proteins, using MBS605963 (upper) or Phospho-Tyrosine mAb (P-Tyr-100) (lower). MBS605963 specifically recognizes the activated Abl of Bcr-Abl fusion proteins, whose phosphorylation was abolished by calf intestinal phosphatase (CIP) treatment.)
c-Abl, Monoclonal Antibody (Cat# AAA605963)
Full Name
c-Abl, phosphorylated (Tyr412) (ABL1, v-abl, Abelson Murine Leukemia Viral Oncogene Homolog 1, ABL, c-ABL, JTK7, p150, Proto-Oncogene Tyrosine-Protein Kanase ABL1, v-abl)
Reactivity
Human, Mouse
Applications
WB
Purity
Supernatant
Supernatant
Supernatant
Pricing
$660/0.1 mL | $2,955/5x0.1 mL
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
c ABL (ABL1), Polyclonal Antibody (Cat# AAA9213319)
Full Name
c ABL (ABL1) Antibody (C-term)
Gene Names
ABL1; ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl
Reactivity
Human
Applications
EIA, IHC-P, WB
Purity
This antibody is purified through a protein A column, followed by peptide affinity purification.
Pricing
$405/0.4 mL | $185/0.08 mL | $1,585/5x0.4 mL
Molecular Structure
PKC-412, Inhibitor (Cat# AAA515011)
Full Name
PKC-412
Purity
98% (TLC) NMR: (Conforms)
Pricing
$225/1 mg | $515/5 mg | $2,085/5x5 mg
Chemical Structure
(Chemical structure of Imatinib mesylate (SIH-453), a BCR-ABL kinase inhibitor. CAS #: 152459-95-5. Molecular Formula: C30H35N7O4S. Molecular Weight: 589.7 g/mol.)
Imatinib mesylate, Small Molecule (Cat# AAA808153)
Full Name
Imatinib mesylate
Purity
>=98% (HPLC)
Pricing
$185/20 mg | $280/100 mg | $1,015/5x100 mg | $605/5x20 mg
Western Blot (WB)
(Western blot analysis of extracts from GM-CSF treated (25 ng/ml) TF-1 cells, using Phospho-Stat5 (Tyr694) Antibody (upper) or control Stat5 antibody (lower).)
STAT 5, Polyclonal Antibody (Cat# AAA626193)
Full Name
STAT 5, phosphorylated (Tyr694) (Signal Transducer and Activator of Transcription 5)
Gene Names
Stat92E; CG4257; d-STAT; D-stat; D-Stat; D-STAT; D-stat/stat92E; DmelCG4257; DmSTAT; DRODSRC; DSRC; dstat; dSTAT; Dstat; DSTAT; Dstat 92E; dSTAT92E; Dstat92E; dSTAT92E/marelle; l(3)06346; l(3)j6C8; mrl; mrL; mrl stat92E; pSTAT; SD-stat; stat; Stat; STAT; STAT 92E;
Reactivity
Human, Mouse, Rat
Applications
EL/EIA, WB, FC/FACS
Purity
Affinity Purified
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Pricing
$660/0.1 mL | $2,955/5x0.1 mL
Molecular Structure
Genistein, Inhibitor (Cat# AAA515015)
Full Name
Genistein
Purity
98% (TLC); NMR (Conforms)
Pricing
$165/10 mg | $255/50 mg | $930/5x50 mg
Testing Data
(Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor with IC50 of 0.37, 2, 1.5, 2.2, 1.1, 1and 0.24 nM for native pan-BCR-ABL, mutated form, VEGFR2, FGFR1, PDGFRalpha, mutant FLT3 phosphorylation and LYN. It potently inhibited other clinically important ABL kinase domain mutants with IC50 from 0.30 to 0.44 nM and inhibited SRC with an IC50 of 5.4 nM. It inhibits the proliferation of mutant FLT3-positive cells with an IC50 of 13 nM and that inhibits mutant FLT3 phosphorylation with an IC50 of 1 nM and the proliferation of BCR-ABL1 T315I-positive Ba/F3 cells with an IC50 of 8 nM. It inhibited all tested BCR-ABL mutants with low nM IC50s in cellular and biochemical assays, suppressed BCR-ABL(T315I)-driven tumor growth in mice, and completely abrogated resistance in cell-based mutagenesis screens. AP24534 is used for treatment of CML. It did not inhibit Aurora kinase family members, nor did it inhibit insulin receptor or cyclin-dependent kinase 2 (CDK2)/Cyclin E (IC50 > 1000-fold relative to native ABL. [1][2][3])
Ponatinib, Inhibitor (Cat# AAA8506540)
Full Name
Ponatinib (AP24534)
Pricing
$440/10 mg | $1,940/5x10 mg
Molecular Structure
Roscovitine, Inhibitor (Cat# AAA515032)
Full Name
Roscovitine
Purity
>99% (TLC); NMR (Conforms)
Pricing
$195/2 mg | $380/10 mg | $1,490/5x10 mg
Dasatinib monohydrate, Inhibitor (Cat# AAA575677)
Full Name
Dasatinib monohydrate
Purity
100.0%
Pricing
$195/25 mg | $215/50 mg | $240/100 mg | $305/200 mg | $195/1 mL (in DMSO) | $1,105/5x200 mg
Structure
WP1130, Inhibitor (Cat# AAA578855)
Full Name
WP1130
Purity
98.0%
Pricing
$205/5 mg | $245/10 mg | $335/25 mg | $490/50 mg | $760/100 mg | $210/1 mL (in DMSO) | $3,145/5x100 mg
Chemical Structure
(Chemical structure of Dasatinib (SIH-440), a Src and Bcr/Abl kinase inhibitor. CAS #: 302962-49-8. Molecular Formula: C22H26ClN7O2S. Molecular Weight: 488 g/mol.)
Dasatinib, Small Molecule (Cat# AAA808140)
Full Name
Dasatinib
Purity
>=98%
Pricing
$190/5 mg | $245/25 mg | $885/5x25 mg | $630/5x5 mg
Structure
PP1, Inhibitor (Cat# AAA578760)
Full Name
PP1
Purity
100.0%
Pricing
$200/2 mg | $230/5 mg | $260/10 mg | $340/25 mg | $405/50 mg | $575/100 mg | $230/1 mL (in DMSO) | $2,330/5x100 mg
Structure
Saracatinib, Inhibitor (Cat# AAA578651)
Full Name
Saracatinib
Purity
98.03%
Pricing
$195/5 mg | $210/10 mg | $260/25 mg | $290/50 mg | $360/100 mg | $570/200 mg | $205/1 mL (in DMSO) | $2,290/5x200 mg
Chemical Structure
(Chemical structure of Nilotinib (SIH-463), a BCR-ABL kinase inhibitor. CAS #: 641571-10-0. Molecular Formula: C28H22F3N7O. Molecular Weight: 529.5 g/mol.)
Nilotinib, Small Molecule (Cat# AAA808163)
Full Name
Nilotinib
Purity
>=99%
Pricing
$190/5 mg | $375/25 mg | $1,450/5x25 mg | $640/5x5 mg
Structure
Bafetinib, Inhibitor (Cat# AAA578865)
Full Name
Bafetinib
Purity
95.0%
Pricing
$205/2 mg | $225/5 mg | $245/10 mg | $295/25 mg | $330/50 mg | $480/100 mg | $590/200 mg | $240/1 mL (in DMSO) | $2,380/5x200 mg
Chemical Structure
Flumatinib, Inhibitor (Cat# AAA5750459)
Full Name
Flumatinib
Purity
100.0%
Pricing
$210/5 mg | $225/10 mg | $265/25 mg | $300/50 mg | $400/100 mg | $545/200 mg | $225/1 mL (in DMSO) | $2,175/5x200 mg
K 0859, Inhibitor (Cat# AAA5750699)
Full Name
K 0859
Purity
98.00%
Pricing
$240/1 mg | $350/5 mg | $1,305/5x5 mg
Structure
Cenisertib, Inhibitor (Cat# AAA5754696)
Full Name
Cenisertib
Purity
98.00%
Pricing
$425/5 mg | $600/10 mg | $1,525/50 mg | $2,035/100 mg | $455/1mL*10mM (in DMSO) | $8,870/5x100 mg
Structure
PP1, Inhibitor (Cat# AAA3602624)
Full Name
PP1
Purity
>98% (HPLC)
Pricing
$190/2 mg | $225/5 mg | $245/10 mg | $320/25 mg | $380/50 mg | $540/100 mg | $2,120/5x100 mg
Chemical Structure
Gypsogenin, Inhibitor (Cat# AAA5764855)
Full Name
Gypsogenin
Purity
0.9861
Pricing
$330/1 mg | $560/5 mg | $810/10 mg | $1,290/25 mg | $1,880/50 mg | $2,740/100 mg | $4,055/200 mg
SDS-Page
(Recombinant ABL1 (229-500) protein gel 10% SDS-PAGE with Coomassie blue staining MW: 32.8 kDa Purity: >90%)
ABL1, Recombinant Protein (Cat# AAA389379)
Full Name
Recombinant ABL1 (229-500) protein
Gene Names
ABL1; ABL; JTK7; p150; c-ABL; v-abl; bcr/abl
Pricing
$565/0.02 mg | $4,215/1 mg | $18,905/5x1 mg
Structure
Nilotinib (monohydrochloride monohydrate), Inhibitor (Cat# AAA5756756)
Full Name
Nilotinib (monohydrochloride monohydrate)
Purity
98.00%
Pricing
$205/100 mg | $260/500 mg | $210/200 mg | $905/5x500 mg
Structure
ZM 306416, Inhibitor (Cat# AAA3605638)
Full Name
ZM 306416
Purity
>98% (HPLC)
Pricing
$200/5 mg | $235/10 mg | $315/25 mg | $470/50 mg | $735/100 mg | $3,035/5x100 mg
Nilotinib hydrochloride, Inhibitor (Cat# AAA5756890)
Full Name
Nilotinib hydrochloride
Purity
98.00%
Pricing
$225/25 mg | $730/5x25 mg
Structure
Dasatinib hydrochloride, Inhibitor (Cat# AAA3606198)
Full Name
Dasatinib hydrochloride
Purity
>98% (HPLC)
Structure
Asciminib, Inhibitor (Cat# AAA3602066)
Full Name
Asciminib
Purity
>98% (HPLC)
Pricing
$240/2 mg | $280/5 mg | $355/10 mg | $565/25 mg | $875/50 mg | $3,645/5x50 mg
Chemical Structure
BCR-ABL-IN-1, Inhibitor (Cat# AAA387253)
Full Name
BCR-ABL-IN-1
Purity
>98%
Pricing
$570/1 mg | $1,610/5 mg | $2,690/10 mg | $7,870/50 mg
Structure
Asciminib, Inhibitor (Cat# AAA3844111)
Full Name
Asciminib
Purity
>98%
Pricing
$145/1 mg | $275/5 mg | $420/10 mg | $1,160/50 mg | $5,175/5x50 mg
Structure
CZC-8004, Inhibitor (Cat# AAA5752392)
Full Name
CZC-8004
Purity
98.00%
Pricing
$195/2 mg | $230/5 mg | $275/10 mg | $420/25 mg | $545/50 mg | $230/1 mL (in DMSO) | $2,180/5x50 mg
Structure
Rasagiline, Inhibitor (Cat# AAA3601493)
Full Name
Rasagiline
Purity
>98% (HPLC)
Pricing
$175/10 mg | $185/25 mg | $190/50 mg | $210/100 mg | $250/200 mg | $855/5x200 mg
Chemical Structure
Nilotinib monohydrochloride monohydrate, Inhibitor (Cat# AAA3840907)
Full Name
Nilotinib monohydrochloride monohydrate
Purity
>98%
Pricing
$190/500 mg | $285/1 g | $140/200 mg | $1,220/5x1 g
Structure
CEP-32496, Inhibitor (Cat# AAA3600648)
Full Name
CEP-32496
Purity
>98% (HPLC)
Pricing
$210/2 mg | $245/5 mg | $310/10 mg | $480/25 mg | $660/50 mg | $2,680/5x50 mg
Structure
Asciminib, Inhibitor (Cat# AAA5751622)
Full Name
Asciminib
Purity
99.45%
Pricing
$235/2 mg | $265/5 mg | $330/10 mg | $475/25 mg | $560/50 mg | $870/100 mg | $275/1 mL (in DMSO) | $3,655/5x100 mg
Chemical Structure
Lyn-IN-1, Inhibitor (Cat# AAA3841531)
Full Name
Lyn-IN-1
Purity
>98%
Pricing
$170/5 mg | $235/10 mg | $650/50 mg | $2,870/5x50 mg
Chemical Structure
Vodobatinib, Inhibitor (Cat# AAA5765037)
Full Name
Vodobatinib
Purity
0.9993
Pricing
$235/1 mg | $310/5 mg | $375/10 mg | $485/25 mg | $625/50 mg | $885/100 mg | $3,720/5x100 mg
Structure
GMB-475, Inhibitor (Cat# AAA5759281)
Full Name
GMB-475
Purity
100.00%
Pricing
$240/1 mg | $330/5 mg | $425/10 mg | $570/25 mg | $795/50 mg | $430/1 mL (in DMSO) | $3,305/5x50 mg
Structure
Structure
Dasatinib, Inhibitor (Cat# AAA3603951)
Full Name
Dasatinib
Purity
>98% (HPLC)
Pricing
$185/100 mg | $215/500 mg | $200/200 mg | $690/5x500 mg
Structure
Ponatinib, Inhibitor (Cat# AAA3606750)
Full Name
Ponatinib
Purity
>98% (HPLC)
Pricing
$190/10 mg | $205/50 mg | $235/100 mg | $265/200 mg | $910/5x200 mg
BCR-ABL-IN-2, Inhibitor (Cat# AAA3845476)
Full Name
BCR-ABL-IN-2
Purity
>98%
Pricing
$420/1 mg | $1,155/5 mg | $1,900/10 mg | $8,485/5x10 mg
CT-721, Inhibitor (Cat# AAA3844195)
Full Name
CT-721
Purity
>98%
Pricing
$420/1 mg | $1,155/5 mg | $1,900/10 mg | $8,485/5x10 mg
Chemical Structure
Radotinib, Inhibitor (Cat# AAA387573)
Full Name
Radotinib (IY-5511)
Purity
>98%
Pricing
$200/10 mg | $295/25 mg | $420/50 mg | $1,840/5x50 mg
Structure
Dasatinib monohydrate, Inhibitor (Cat# AAA3606245)
Full Name
Dasatinib monohydrate
Purity
>98% (HPLC)
Pricing
$190/25 mg | $210/50 mg | $235/100 mg | $295/200 mg | $1,040/5x200 mg
Structure
GNF-2, Inhibitor (Cat# AAA3605932)
Full Name
GNF-2
Purity
>98% (HPLC)
Pricing
$210/2 mg | $235/5 mg | $275/10 mg | $435/25 mg | $545/50 mg | $785/100 mg | $3,235/5x100 mg
Structure
PD-173955, Inhibitor (Cat# AAA3608317)
Full Name
PD-173955
Purity
>98% (HPLC)
Pricing
$225/2 mg | $285/5 mg | $380/10 mg | $650/25 mg | $2,645/5x25 mg
Structure
Structure
GNF-5, Inhibitor (Cat# AAA3605933)
Full Name
GNF-5
Purity
>98% (HPLC)
Pricing
$200/10 mg | $215/25 mg | $260/50 mg | $310/100 mg | $440/200 mg | $1,685/5x200 mg
Structure
Nocodazole, Inhibitor (Cat# AAA3604016)
Full Name
Nocodazole
Purity
>98% (HPLC)
Pricing
$185/5 mg | $200/10 mg | $235/25 mg | $295/50 mg | $390/100 mg | $600/200 mg | $2,410/5x200 mg
