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26 results for " p110alpha p110beta p110delta p110gamma" - showing 1-26
Testing Data #1
(Paraffin embedded human brain (cerebellar cortex) stained with Goat anti human p110alpha (MBS223510))
PI-3 KINASE p110 SUBUNIT ALPHA, Polyclonal Antibody (Cat# AAA223510)
Full Name
GOAT ANTI HUMAN PI-3 KINASE p110 SUBUNIT ALPHA
Gene Names
PIK3CA; MCM; CWS5; MCAP; PI3K; CLOVE; MCMTC; p110-alpha
Reactivity
Bovine (Expected from Sequence), Dog (Expected from Sequence), Mouse (Expected from Sequence), Rat (Expected from Sequence)
Applications
EIA
Pricing
$625/0.1 mg | $2,670/5x0.1 mg
Testing Data
(PP242 is a novel potent and selective mTOR inhibitor with an IC50 of 8 nM. PP242 also shows residual (micromolar) activity against panel of tyrosine kinases. But PP242 was much less active against other PI3K family members with IC50 of 2, 2.2, 0.1, 1.3 and 0.41 uM for p110alpha, p110beta, p110delta, p110gamma and DNA-PK, respectively. PP242 inhibits other PI 3-Kinases only at much higher concentrations. PP242, but not rapamycin, causes death of mouse and human leukemia cells. In vivo, PP242 delays leukemia onset and augments the effects of the current front-line tyrosine kinase inhibitors more effectively than does rapamycin. PP242 was also more effective than rapamycin in achieving cytoreduction and apoptosis in multiple myeloma cells. In addition, PP242 was an effective agent against primary multiple myeloma cells in vitro and growth of 8226 cells in mice. Knockdown of the TORC2 complex protein, rictor, was deleterious to multiple myeloma cells further supporting TORC2 as the critical target for PP242. [1][2][3])
Testing Data
(PI-103 is a potent, cell-permeable, ATP-competitive PI3K family members inhibitor with IC50 of 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110alpha, mTORC1, PI3-KC2beta, p110delta, mTORC2, p110beta, and p110gamma, respectively. It shows little activity against a wide array of protein kinases at 10 mM. It blocks glioma proliferation by blocking the PI 3-K/Akt pathway in vitro and in vivo. PI-103 was essentially cytostatic for cell lines and induced cell cycle arrest in the G1 phase. In blast cells, PI-103 inhibited leukemic proliferation, the clonogenicity of leukemic progenitors and induced mitochondrial apoptosis, especially in the compartment containing leukemic stem cells. PI-103 had additive proapoptotic effects with etoposide in blast cells and in immature leukemic cells. [1][2][3])
PIK3CG, Polyclonal Antibody (Cat# AAA1488604)
Full Name
Rabbit Anti Human PIK3CG PolyClonal Antibody
Reactivity
Human, Mouse, Rat
Applications
WB
Purity
Affinity Purification
Pricing
$325/0.1 mL | $1,465/5x0.1 mL
Testing Data
(PP121 is a multitargeted dual receptor tyrosine kinases inhibitor with IC50 of 0.052, 1.4, 0.15, 1.1, 0.06, 0.01and 0.002 uM for p110alpha, p110beta, p110delta, p110gamma, DNA-PK, mTOR and PDGFR, respectively. PP121 also inhibits Abl, Hck, Src,Src(T338I), VEGFR2, EGFR EphB4 with IC50 of 0.018, 0.008, 0.014, 0.22, 0.012, 0.26, 0.19 uM, respectively. PP121 exhibits no significant effect on receptor serine/threonine kinases (RSTKs). PP121 blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor. PP121 achieves its dual potency by targeting a residue (Glu310 in Src) that has been structurally conserved between kinase families. PP121 potently and dose-dependently blocked the phosphorylation of Akt, p70S6K and S6 in these cells. [1])
Structure
PI-103, Inhibitor (Cat# AAA578711)
Full Name
PI-103
Purity
97.59%
Pricing
$205/5 mg | $210/10 mg | $265/25 mg | $330/50 mg | $490/100 mg | $745/200 mg | $205/1 mL (in DMSO) | $3,080/5x200 mg
Structure
Pictilisib dimethanesulfonate, Inhibitor (Cat# AAA5753177)
Full Name
Pictilisib dimethanesulfonate
Purity
98.00%
Pricing
$200/5 mg | $215/10 mg | $265/25 mg | $325/50 mg | $400/100 mg | $550/200 mg | $230/1 mL (in DMSO) | $2,210/5x200 mg
Structure
MLN1117, Inhibitor (Cat# AAA3601125)
Full Name
MLN1117
Purity
>98% (HPLC)
Pricing
$200/2 mg | $225/5 mg | $255/10 mg | $360/25 mg | $455/50 mg | $620/100 mg | $2,490/5x100 mg
Structure
Idelalisib, Inhibitor (Cat# AAA3606318)
Full Name
Idelalisib
Purity
>98% (HPLC)
Pricing
$190/5 mg | $200/10 mg | $205/25 mg | $240/50 mg | $250/100 mg | $320/200 mg | $1,145/5x200 mg
Structure
TGX-221, Inhibitor (Cat# AAA3605527)
Full Name
TGX-221
Purity
>98% (HPLC)
Pricing
$190/2 mg | $210/5 mg | $245/10 mg | $370/25 mg | $455/50 mg | $645/100 mg | $2,610/5x100 mg
Structure
CAL-130 Hydrochloride, Inhibitor (Cat# AAA5752847)
Full Name
CAL-130 Hydrochloride
Purity
98.00%
Pricing
$295/2 mg | $360/5 mg | $420/10 mg | $915/50 mg | $365/1mL*10mM (in DMSO) | $3,835/5x50 mg
Structure
PIK-93, Inhibitor (Cat# AAA3605200)
Full Name
PIK-93
Purity
>98% (HPLC)
Pricing
$190/2 mg | $220/5 mg | $275/10 mg | $395/25 mg | $1,475/5x25 mg
Structure
GDC-0941, Inhibitor (Cat# AAA3606828)
Full Name
GDC-0941
Purity
>98% (HPLC)
Pricing
$185/5 mg | $190/10 mg | $205/50 mg | $235/100 mg | $300/200 mg | $1,045/5x200 mg
Structure
Omipalisib, Inhibitor (Cat# AAA3600336)
Full Name
Omipalisib
Purity
>98% (HPLC)
Pricing
$230/2 mg | $250/5 mg | $295/10 mg | $445/25 mg | $1,705/5x25 mg
Structure
Dactolisib Tosylate, Inhibitor (Cat# AAA5754600)
Full Name
Dactolisib Tosylate
Purity
98.00%
Pricing
$210/50 mg | $235/100 mg | $405/500 mg | $290/200 mg | $215/1mL*10mM (in DMSO) | $1,535/5x500 mg
Structure
PF-4989216, Inhibitor (Cat# AAA3607230)
Full Name
PF-4989216
Purity
>98% (HPLC)
Pricing
$200/2 mg | $235/5 mg | $300/10 mg | $445/25 mg | $635/50 mg | $755/100 mg | $3,120/5x100 mg
Structure
Buparlisib Hydrochloride, Inhibitor (Cat# AAA5755293)
Full Name
Buparlisib Hydrochloride
Purity
98.00%
Pricing
$230/5 mg | $275/10 mg | $425/50 mg | $605/100 mg | $235/1mL*10mM (in DMSO) | $2,440/5x100 mg
Structure
Dactolisib, Inhibitor (Cat# AAA3606565)
Full Name
Dactolisib
Purity
>98% (HPLC)
Pricing
$200/50 mg | $205/100 mg | $240/200 mg | $795/5x200 mg
Structure
PIK-293, Inhibitor (Cat# AAA3607644)
Full Name
PIK-293
Purity
>98% (HPLC)
Pricing
$205/2 mg | $250/5 mg | $340/10 mg | $440/25 mg | $1,700/5x25 mg
Structure
PI-103, Inhibitor (Cat# AAA3604281)
Full Name
PI-103
Purity
>98% (HPLC)
Pricing
$200/5 mg | $205/10 mg | $250/25 mg | $315/50 mg | $455/100 mg | $685/200 mg | $2,795/5x200 mg
Structure
PIK-75, Inhibitor (Cat# AAA3604286)
Full Name
PIK-75
Purity
>98% (HPLC)
Pricing
$190/10 mg | $215/25 mg | $250/50 mg | $300/100 mg | $430/200 mg | $1,650/5x200 mg
Structure
PIK-294, Inhibitor (Cat# AAA3606463)
Full Name
PIK-294
Purity
>98% (HPLC)
Pricing
$200/2 mg | $230/5 mg | $275/10 mg | $370/25 mg | $455/50 mg | $650/100 mg | $2,630/5x100 mg
Structure
GDC-0980, Inhibitor (Cat# AAA3600158)
Full Name
GDC-0980
Purity
>98% (HPLC)
Pricing
$190/2 mg | $205/5 mg | $225/10 mg | $295/25 mg | $495/100 mg | $1,940/5x100 mg
Structure
PIK75, Inhibitor (Cat# AAA3608479)
Full Name
PIK75
Purity
>98% (HPLC)
Pricing
$185/5 mg | $200/10 mg | $240/25 mg | $310/50 mg | $440/100 mg | $690/200 mg | $2,830/5x200 mg
Structure
NVP-BKM120, Inhibitor (Cat# AAA3606760)
Full Name
NVP-BKM120
Purity
>98% (HPLC)
Pricing
$200/5 mg | $210/10 mg | $235/50 mg | $250/100 mg | $330/200 mg | $1,195/5x200 mg
Structure
IPI-3063, Inhibitor (Cat# AAA5755004)
Full Name
IPI-3063
Purity
98.00%
Pricing
$240/2 mg | $310/5 mg | $425/10 mg | $740/25 mg | $1,050/50 mg | $1,505/100 mg | $315/1 mL (in DMSO) | $6,500/5x100 mg
