Related Product Information for SCARB1 / CD36L1 / CLA-1 recombinant protein
Background: Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane. SCARB1 is proposed as a receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells, and is involved in a wide variety of physilogical processes. As a key component in the reverse cholesterol transport pathway, SCARB1 binds high density lipoproteins (HDLs) and mediates selective cholesterol uptake by a mechanism distinct from the LDL pathway. High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SCARB1 may thus serve as a useful marker that predicts variation in baseline lipid levels and postprandial lipid response. The mouse SCARB1 has been shown to exert actions in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
Description: A DNA sequence encoding the mature form of mouse SRB1 (NP_058021.1) extracellular domain (Pro 33-Val 440) was fused with a polyhistidine tag at the C-terminus.
Uniprot Description
SCARB1: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester. Belongs to the CD36 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of Human Ortholog: 5 64.11 cM|5 G1.1
Cellular Component: caveola; cell surface; cytoplasm; integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; lysosomal membrane; microvillus membrane; plasma membrane
Molecular Function: apolipoprotein A-I binding; apolipoprotein binding; high-density lipoprotein binding; lipopolysaccharide binding; lipopolysaccharide receptor activity; low-density lipoprotein binding; phosphatidylserine binding; protein homodimerization activity
Biological Process: adhesion to host; androgen biosynthetic process; blood vessel endothelial cell migration; cholesterol catabolic process; cholesterol efflux; cholesterol homeostasis; cholesterol transport; detection of lipopolysaccharide; endothelial cell proliferation; intestinal absorption; lipid transport; lipopolysaccharide transport; phagocytosis, recognition; phospholipid transport; positive regulation of nitric-oxide synthase activity; recognition of apoptotic cell; regulation of phagocytosis; reverse cholesterol transport
Product Notes
The SCARB1 / CD36L1 / CLA-1 scarb1 (Catalog #
AAA2547039) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The secreted recombinant mouse SRB1 comprises 419 amino acids with a predicted molecular mass of 47 kDa. As a result of glycosylation, it migrates as an approximately 70-90 kDa band in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the SCARB1 / CD36L1 / CLA-1 scarb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"SCARB1 / CD36L1 / CLA-1, Recombinant Protein" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
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