Scavenger Receptor Class A Member 5 Recombinant Protein | SCARA5 recombinant protein

Recombinant Scavenger Receptor Class A Member 5 (SCARA5)

Cat. Num. AAA2032931

• Gene Names: SCARA5; Tesr; NET33
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >90%
• Synonyms: Scavenger Receptor Class A Member 5; Recombinant Scavenger Receptor Class A Member 5 (SCARA5); NET33; Scavenger receptor hlg; SCARA5 recombinant protein

• Host: E Coli
• Purity/Purification: >90%
• Form/Format: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Sequence: QAD LTEQVWKVQD ALQNQSDSLL ALAGAVQRLEGALWGLQAQA VQTEQAVALL RDRTGQQSDT AQLELYQLQV ESNSSQLLLRRHAGLLDGLA RRVGILGEEL ADVGGVLRGL NHSLSYDVAL HRTRLQDLRVLVSNASEDTR RLRLAHVGME LQLKQELAML NAVTEDLRLK DWEHSIALRNISLAKGPPGP KGDQGDEGKE GRPGIPGLPG LRGLPGERGT PGLPGPKGDDGKLGATGPMG MRGFKGDRGP KGEKGEKGDR AGDASGVEAP MMIRLVNGSGPHEGRVEVYH DRRWGTVCDD GWDKKDGDVV CRMLGFRGVE EVYRTARFGQGTGRIWMDDV ACKGTEETIF RCSFSKWGVT NCGHAEDASV TCNRH
• Sequence Length: 495

• Applicable Applications for SCARA5 recombinant protein: SDS-PAGE, Western (WB), ELISA (EIA), Immunoprecipitation (IP).
• Predicted Molecular Mass: 44.7kDa
• Usage: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Endotoxin Level: <1.0EU per 1 ug (determined by the LAL method)
• Expression System: Prokaryotic expression
• Fragment: Gln118~His495
• Organism Species: Human
• Tag: two N-terminal Tags, His-tag and T7-tag
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 47271477
• NCBI GeneID: 286133
• NCBI Accession #: NP_776194.2
• NCBI GenBank Nucleotide #: NM_173833.5
• Molecular Weight: 28,871 Da
• NCBI Official Full Name: scavenger receptor class A member 5
• NCBI Official Synonym Full Names: scavenger receptor class A member 5
• NCBI Official Symbol: SCARA5
• NCBI Official Synonym Symbols: Tesr; NET33
• NCBI Protein Information: scavenger receptor class A member 5
• UniProt Protein Name: Scavenger receptor class A member 5
• Protein Family: Scavenger receptor
• UniProt Gene Name: SCARA5
• UniProt Entry Name: SCAR5_HUMAN

Uniprot Description

SCARA5: Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1). Belongs to the SCARA5 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p21.1

Cellular Component: cell surface; integral to plasma membrane

Molecular Function: scavenger receptor activity

Biological Process: cellular iron ion homeostasis; endocytosis; receptor-mediated endocytosis; regulation of blood coagulation; regulation of gene expression