Store-operated calcium entry-associated regulatory factor Recombinant Protein | SARAF recombinant protein
Recombinant Human Store-operated calcium entry-associated regulatory factor
Gene Names
SARAF; XTP3; FOAP-7; TMEM66; HSPC035
Reactivity
Human
Purity
Greater than 90% as determined by SDS-PAGE.
Synonyms
Store-operated calcium entry-associated regulatory factor; Recombinant Human Store-operated calcium entry-associated regulatory factor; HBV X-transactivated gene 3 proteinHBV XAg-transactivated protein 3; Protein FOAP-7Transmembrane protein 66; SARAF recombinant protein
Host
E Coli
Reactivity
Human
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
20mM Tris-HCl based buffer, pH8.0
Sequence Positions
Full Length of Cytoplasmic, 195-339aa
Tag Info
His-SUMO-tag
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Related Product Information for SARAF recombinant protein
Negative regulator of store-operated Ca2+ entry (SOCE) involved in protecting cells from Ca2+ overfilling. In response to cytosolic Ca2+ elevation after endoplasmic reticulum Ca2+ refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca2+ levels, and thus preventing the overload of the cell with excessive Ca2+ ions.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
31.48kD
NCBI Official Full Name
store-operated calcium entry-associated regulatory factor isoform 2
NCBI Official Synonym Full Names
store-operated calcium entry associated regulatory factor
NCBI Official Symbol
SARAF
NCBI Official Synonym Symbols
XTP3; FOAP-7; TMEM66; HSPC035
NCBI Protein Information
store-operated calcium entry-associated regulatory factor
UniProt Protein Name
Store-operated calcium entry-associated regulatory factor
Protein Family
UniProt Gene Name
SARAF
UniProt Synonym Gene Names
TMEM66; XTP3; SARAF; SOCE-associated regulatory factor
Uniprot Description
TMEM66: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. Belongs to the SARAF family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 8p12
Cellular Component: endoplasmic reticulum; integral to endoplasmic reticulum membrane
Molecular Function: protein binding
Research Articles on SARAF
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Product Notes
The SARAF saraf (Catalog #AAA9421343) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Full Length of Cytoplasmic, 195-339aa. The Recombinant Human Store-operated calcium entry-associated regulatory factor reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Store-operated calcium entry-associated regulatory factor, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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