Tyrosine-protein kinase RYK Recombinant Protein | RYK recombinant protein
Tyrosine-protein kinase RYK
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Uniprot Description
RYK: a receptor tyrosine kinase of the Ryk family. Associates with, and may modulate the signaling of, EphB2 and EphB3. Expressed in nestin-positive progenitor cells and neurons, some oligodendrocytes, O-2A progenitor cells, and type-2 astrocytes in developing CNS.
Protein type: Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Kinase, protein; EC 2.7.10.1; TK group; Ryk family
Chromosomal Location of Human Ortholog: 3q22
Cellular Component: cytoplasm; integral to plasma membrane; membrane; nucleus; plasma membrane
Molecular Function: frizzled binding; protein binding; protein-tyrosine kinase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity; Wnt receptor activity; Wnt-protein binding
Biological Process: axon guidance; axonogenesis; cell proliferation in midbrain; corpus callosum development; neurite development; neuron differentiation; positive regulation of MAPKKK cascade; protein amino acid phosphorylation; signal transduction; Wnt receptor signaling pathway
Research Articles on RYK
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Product Notes
The RYK ryk (Catalog #AAA7043264) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 26-607. Full length of the mature protein. The amino acid sequence is listed below: PPPLLLLLAL LPLLPAPGAA AAPAPRPPEL QSASAGPSVS LYLSEDEVRR LIGLDAELYY VRNDLISHYA LSFSLLVPSE TNFLHFTWHA KSKVEYKLGF QVDNVLAMDM PQVNISVQGE VPRTLSVFRV ELSCTGKVDS EVMILMQLNL TVNSSKNFTV LNFKRRKMCY KKLEEVKTSA LDKNTSRTIY DPVHAAPTTS TRVFYISVGV CCAVIFLVAI ILAVLHLHSM KRIELDDSIS ASSSSQGLSQ PSTQTTQYLR ADTPNNATPI TSYPTLRIEK NDLRSVTLLE AKGKVKDIAI SRERITLKDV LQEGTFGRIF HGILIDEKDP NKEKQAFVKT VKDQASEIQV TMMLTESCKL RGLHHRNLLP ITHVCIEEGE KPMVILPYMN WGNLKLFLRQ CKLVEANNPQ AISQQDLVHM AIQIACGMSY LARREVIHKD LAARNCVIDD TLQVKITDNA LSRDLFPMDY HCLGDNENRP VRWMALESLV NNEFSSASDV WAFGVTLWEL MTLGQTPYVD IDPFEMAAYL KDGYRIAQPI NCPDELFAVM ACCWALDPEE RPKFQQLVQC LTEFHAALGA YV. It is sometimes possible for the material contained within the vial of "Tyrosine-protein kinase RYK, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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