Western Blot (WB)
(Western blot analysis of CDNF in mouse brain tissue lysate with CDNF antibody at (A) 2 and (B) 4 ug/mL.)
Rabbit CDNF Polyclonal Antibody | anti-CDNF antibody
CDNF Antibody
Gene Names
CDNF; ARMETL1
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Affinity chromatography purified via peptide column
Synonyms
CDNF; Polyclonal Antibody; CDNF Antibody; Conserved dopamine neurotrophic factor; arginine-rich; mutated in early stage tumors-like 1; ARMET-like 1; ARMETL1; anti-CDNF antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
This antibody does not cross-react with MANF.
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
187
Applicable Applications for anti-CDNF antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Immunogen Type
Peptide
Immunogen Description
Raised against a 9 amino acid peptide from near the carboxy terminus of human CDNF.
Target Name
CDNF
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of CDNF in mouse brain tissue lysate with CDNF antibody at (A) 2 and (B) 4 ug/mL.)
Western Blot (WB)
(Western blot analysis of CDNF in mouse brain tissue lysate with CDNF antibody at (A) 2 and (B) 4 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of CDNF in human brain tissue with CDNF antibody at 2.5 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of CDNF in human brain tissue with CDNF antibody at 2.5 ug/mL.)
Related Product Information for anti-CDNF antibody
The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson's disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson's disease. At least two isoforms of CDNF are known to exist.
Product Categories/Family for anti-CDNF antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
9,806 Da
NCBI Official Full Name
cerebral dopamine neurotrophic factor
NCBI Official Synonym Full Names
cerebral dopamine neurotrophic factor
NCBI Official Symbol
CDNF
NCBI Official Synonym Symbols
ARMETL1
NCBI Protein Information
cerebral dopamine neurotrophic factor
UniProt Protein Name
Cerebral dopamine neurotrophic factor
Protein Family
UniProt Gene Name
CDNF
UniProt Synonym Gene Names
ARMETL1
UniProt Entry Name
CDNF_HUMAN
Uniprot Description
ARMETL1: Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra. Belongs to the ARMET family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10p13
Cellular Component: extracellular region
Molecular Function: growth factor activity
Research Articles on CDNF
Similar Products
Product Notes
The CDNF cdnf (Catalog #AAA9412916) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CDNF Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CDNF can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the CDNF cdnf for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDNF, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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