Rabbit anti-Human RYK Polyclonal Antibody | anti-RYK antibody

RYK Antibody

Cat. Num. AAA9418684

• Gene Names: RYK; JTK5; RYK1; JTK5A; D3S3195
• Reactivity: Human
• Applications: Western Blot
• Synonyms: RYK; Polyclonal Antibody; RYK Antibody; D3S3195; Hydroxyaryl-protein kinase; JTK5; JTK5A protein tyrosine kinase; RYK1; Vik; Tyrosine-protein kinase RYK; Receptor-like tyrosine kinase; JTK5A; Tyrosine kinase ryk; anti-RYK antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: RYK Antibody detects endogenous levels of total RYK
• Form/Format: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0mg/mL (varies by lot)
• Sequence Length: 610

• Applicable Applications for anti-RYK antibody: Western Blot (WB)
• Application Notes: Western Blot: 1:1000-3000
• Immunogen: A synthesized peptide derived from human RYK
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis RYK using K562 whole cell lysates)

Product Categories/Family for anti-RYK antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 54607020
• NCBI GeneID: 6259
• NCBI Accession #: NP_001005861.1
• NCBI GenBank Nucleotide #: NM_001005861.2
• UniProt Accession #: P34925; Q04696
• Molecular Weight: 67,764 Da
• NCBI Official Full Name: tyrosine-protein kinase RYK isoform 1
• NCBI Official Synonym Full Names: receptor-like tyrosine kinase
• NCBI Official Symbol: RYK
• NCBI Official Synonym Symbols: JTK5; RYK1; JTK5A; D3S3195
• NCBI Protein Information: tyrosine-protein kinase RYK
• UniProt Protein Name: Tyrosine-protein kinase RYK
• Protein Family: Tyrosine-protein kinase
• UniProt Gene Name: RYK
• UniProt Synonym Gene Names: JTK5A
• UniProt Entry Name: RYK_HUMAN

NCBI Description

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

Uniprot Description

RYK: a receptor tyrosine kinase of the Ryk family. Associates with, and may modulate the signaling of, EphB2 and EphB3. Expressed in nestin-positive progenitor cells and neurons, some oligodendrocytes, O-2A progenitor cells, and type-2 astrocytes in developing CNS.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ryk family; TK group

Chromosomal Location of Human Ortholog: 3q22

Cellular Component: cytoplasm; integral to plasma membrane; membrane; nucleus; plasma membrane

Molecular Function: frizzled binding; protein binding; protein-tyrosine kinase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity; Wnt receptor activity; Wnt-protein binding

Biological Process: axon guidance; axonogenesis; cell proliferation in midbrain; corpus callosum development; neurite development; neuron differentiation; positive regulation of MAPKKK cascade; protein amino acid phosphorylation; signal transduction; Wnt receptor signaling pathway