Nogo-66 Receptor/Reticulon 4 Receptor Recombinant Protein | RTN4R recombinant protein

Recombinant Human Nogo-66 Receptor/Reticulon 4 Receptor Protein

Cat. Num. AAA2556715

• Gene Names: RTN4R; NGR; NOGOR
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Synonyms: Nogo-66 Receptor/Reticulon 4 Receptor; Recombinant Human Nogo-66 Receptor/Reticulon 4 Receptor Protein; Reticulon-4 Receptor; Nogo Receptor; NgR; Nogo-66 Receptor; RTN4R; NOGOR; RTN4R recombinant protein

• Host: Human Cells
• Purity/Purification: > 95 % as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
• Sequence Positions: Cys27-Ser447

• Species: Human
• Tag: C-6His
• Endotoxin: < 1.0 EU per ?g as determined by the LAL method.
• Reconstitution: We recommend that the vial be centrifuged to opening to bring the contents to the bottom. Do not mix by vortex. It is recommended that sterile water(200?l) be added to the vial to prepare a stock solution of 0.25 mg/mL. Concentration is measured by UV-Vis.
• Preparation and Storage: Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C.; Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

SDS-Page

Related Product Information for RTN4R recombinant protein

Nogo Receptor (NgR) is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family. Human NgR is predominantly expressed in neurons and their axons in the central nervous systems. As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG) and myelin oligodendrocyte glycoprotein (OMG), NgR mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. NgR may be proposed as a potential drug target for treatment of various neurological conditions. Additionally, NgR may play a role in regulating the function of gap junctions.

NCBI and Uniprot Product Information

• NCBI GI #: 13194201
• NCBI GeneID: 65078
• NCBI Accession #: NP_075380.1
• NCBI GenBank Nucleotide #: NM_023004.6
• UniProt Accession #: Q9BZR6; D3DX28
• Molecular Weight: Mol_Mass: 46.3 kDa; AP_Mol_Mass: 60-90 kDa
• NCBI Official Full Name: reticulon-4 receptor
• NCBI Official Synonym Full Names: reticulon 4 receptor
• NCBI Official Symbol: RTN4R
• NCBI Official Synonym Symbols: NGR; NOGOR
• NCBI Protein Information: reticulon-4 receptor
• UniProt Protein Name: Reticulon-4 receptor
• Protein Family: Reticulon-4 receptor
• UniProt Gene Name: RTN4R
• UniProt Synonym Gene Names: NOGOR; NgR

NCBI Description

This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (). Can also bind heparin (). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).