Active regulator of SIRT1 protein Recombinant Protein | RPS19 recombinant protein

Recombinant human Active regulator of SIRT1 protein

Cat. Num. AAA717190

• Gene Names: RPS19; DBA; S19; DBA1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Active regulator of SIRT1 protein; Recombinant human Active regulator of SIRT1 protein; RPS19 recombinant protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence: MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVARRVLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAANKKH

• Preparation and Storage: Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C.

SDS-PAGE

NCBI and Uniprot Product Information

• NCBI GI #: 48255921
• NCBI GeneID: 6223
• NCBI Accession #: NP_001013.1
• NCBI GenBank Nucleotide #: NM_001022.3
• UniProt Accession #: P39019
• Molecular Weight: 43 KD
• NCBI Official Full Name: Homo sapiens ribosomal protein S19 (RPS19), mRNA
• NCBI Official Synonym Full Names: ribosomal protein S19
• NCBI Official Symbol: RPS19
• NCBI Official Synonym Symbols: DBA; S19; DBA1
• NCBI Protein Information: 40S ribosomal protein S19
• UniProt Protein Name: 40S ribosomal protein S19
• Protein Family: Ribosomal protein
• UniProt Gene Name: RPS19
• UniProt Entry Name: RS19_HUMAN

NCBI Description

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Ref.8

Subunit structure: Interacts with RPS19BP1

By similarity.

Subcellular location: Nucleus. Note: Located more specifically in the nucleoli. Ref.9 Ref.15

Tissue specificity: Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.

Involvement in disease: Defects in RPS19 are the cause of Diamond-Blackfan anemia type 1 (DBA1) [

MIM:105650]. DBA1 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Ref.2 Ref.9 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18

Sequence similarities: Belongs to the ribosomal protein S19e family.