MST4 Blocking Peptide | RP6-213H19.1 blocking peptide

MST4 Immunizing Peptide

Cat. Num. AAA425343

• Gene Names: STK26; MASK; MST4
• Reactivity: Human, Mouse, Rat, Dog, Pig, Cow
• Synonyms: MST4; MST4 Immunizing Peptide; RP6-213H19.1; serine/threonine protein kinase MST4; MASK; Mst3 and SOK1-related kinase; STE20-like kinase MST4; mammalian Ste20-like protein kinase 4; mammalian sterile 20-like 4; serine/threonine protein kinase MASK; RP6-213H19.1 blocking peptide

• Reactivity: Human, Mouse, Rat, Dog, Pig, Cow
• Form/Format: 100ug of dried peptide
• Sequence: KLIEKFQKCSADESP
• Sequence Length: 416

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 15011880
• NCBI GeneID: 51765
• NCBI Accession #: NP_057626.2; NP_001035918.1; NP_001035917.1
• NCBI GenBank Nucleotide #: NM_016542.3
• Molecular Weight: 39,658 Da
• NCBI Official Full Name: serine/threonine-protein kinase 26 isoform 1
• NCBI Official Synonym Full Names: serine/threonine protein kinase 26
• NCBI Official Symbol: STK26
• NCBI Official Synonym Symbols: MASK; MST4
• NCBI Protein Information: serine/threonine-protein kinase 26
• UniProt Protein Name: Serine/threonine-protein kinase 26
• UniProt Gene Name: STK26
• UniProt Synonym Gene Names: MST-4Curated; STE20-like kinase MST4Curated
• UniProt Entry Name: STK26_HUMAN

NCBI Description

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

MST4: a S/T protein kinase of the STE20 family. Mst kinases regulate processes such as apoptosis, morphogenesis, and cytoskeletal rearrangements, and are upstream activators of MAPK pathways that. The amino-terminal kinase domain of Mst is considerably homologous to the kinase domain of yeast STE20 kinase and other p21-activated kinases. otential mediator of cell growth. Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage.

Protein type: Protein kinase, STE; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; YSK subfamily

Chromosomal Location of Human Ortholog: Xq26.2

Cellular Component: apical plasma membrane; centrosome; cytoplasm; cytosol; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; nucleus; perinuclear region of cytoplasm

Molecular Function: ATP binding; identical protein binding; magnesium ion binding; protein binding; protein homodimerization activity; protein kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: cell structure disassembly during apoptosis; microvillus biogenesis; mitotic cell cycle; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell differentiation; response to hydrogen peroxide