Ro-60/SS-A Antigen Recombinant Protein
Ro-60/SS-A Antigen (60kD), Recombinant, Human (SSA1, Sjogren Syndrome Antigen A1, 52kD Ribonucleoprotein Autoantigen SS-A/Ro, RO52, RNF81, Tripartite Motif Protein 21, TRIM21)
Purity
>=90% by (SDS-PAGE)
Synonyms
Ro-60/SS-A Antigen; Ro-60/SS-A Antigen (60kD); Recombinant; Human (SSA1; Sjogren Syndrome Antigen A1; 52kD Ribonucleoprotein Autoantigen SS-A/Ro; RO52; RNF81; Tripartite Motif Protein 21; TRIM21); 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa ribonucleoprotein Ro; RoRNP; 60 kDa Ro protein; Ro 60 kDa autoantigen; TROVE domain family member 2; Sjoegren syndrome type A antigen; SS-A; Sjoegren syndrome antigen A2; TROVE2; RO60; SSA2; RO-60.; Ro-60/SS-A Antigen recombinant protein
Host
E. coli
Purity/Purification
>=90% by (SDS-PAGE)
Form/Format
Supplied as a liquid in 10mM Tris, pH 6.0., 6M Urea, 500mM sodium chloride, 500mM imidazole
Concentration
0.671mg/ml (varies by lot)
Protein Content
Protein quantitation was carried out by using 0.5 - 2.0 mg/ml Bradford assay vs. BSA.
Preparation and Storage
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for Ro-60/SS-A Antigen recombinant protein
The SS-A/Ro particle contains a hY RNA (human cytoplasmic RNA) and associated proteins: a 60kD and a 52kD protein. The 52kD protein is not directly bound to the hY RNA but to the 60kD protein. It seems that it is sometimes associated, sometimes not. The Ro antigen is found in the cytoplasm but also in the nucleus. An RNA-binding protein, the Ro 60kD autoantigen, is a major target of the immune response in patients suffering from two systemic rheumatic diseases, systemic lupus erythematosus and Sjogren's syndrome. In lupus patients, anti-Ro antibodies are associated with photosensitive skin lesions and with neonatal lupus, a syndrome in which mothers with anti-Ro antibodies give birth to children with photosensitive skin lesions and a cardiac conduction defect, third degree heart block. In vertebrate cells, the Ro protein binds small RNAs of unknown function known as Y RNAs. Although the cellular function of Ro has long been mysterious, recent studies have implicated Ro in two distinct processes: small RNA quality control and the enhancement of cell survival following exposure to ultraviolet irradiation. Most interestingly, mice lacking the Ro protein develop an autoimmune syndrome that shares some features with systemic lupus erythematosus in patients, suggesting that the normal function of Ro may be important for the prevention of this autoimmune disease.
Product Categories/Family for Ro-60/SS-A Antigen recombinant protein
Similar Products
Product Notes
The Ro-60/SS-An Antigen (Catalog #AAA635764) is a Recombinant Protein produced from E. coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ro-60/SS-A Antigen, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
