Rabbit TROVE2 Polyclonal Antibody | anti-TROVE2 antibody

TROVE2 Polyclonal Antibody

Cat. Num. AAA3006185

• Gene Names: RO60; SSA2; RORNP; TROVE2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TROVE2; Polyclonal Antibody; TROVE2 Polyclonal Antibody; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa Ro protein; 60 kDa ribonucleoprotein Ro; RoRNP; Ro 60 kDa autoantigen; Sjoegren syndrome antigen A2; Sjoegren syndrome type A antigen; SS-A; TROVE domain family member 2; RO60; SSA2; 60 kDa Ro/SSA; anti-TROVE2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TROVE2 polyclonal antibody detects endogenous levels of TROVE2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 525

• Applicable Applications for anti-TROVE2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 361-406 of Human TROVE2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of TROVE2 polyclonal antibody at 1:500 dilutionLane1:Hela cell lysateLane2:Mouse brain tissue lysateLane3:Rat brain tissue lysate)

Related Product Information for anti-TROVE2 antibody

Ro autoantigens are of clinical significance because antibodies directed against them are found in most patients with primary Sjogren syndrome, subacute cutaneous lupus erythematosus (SLE), neonatal lupus erythematosus, ANA-negative lupus erythematosus, and systemic lupus erythematosus-like disease secondary to homozygous C2 or C4 complement deficiency. Ro/SSA is a ribonucleoprotein that binds to autoantibodies in 35 to 50% of patients with SLE and in up to 97% of patients with Sjogren syndrome. The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecules. Most anti-Ro/SSA-positive sera antibodies detect not only the main protein, but also a smaller Ro/SSA protein.

NCBI and Uniprot Product Information

• NCBI GI #: 108796056
• NCBI GeneID: 6738
• NCBI Accession #: NP_001035828.1
• NCBI GenBank Nucleotide #: NP_001035828.1
• UniProt Accession #: P10155
• Molecular Weight: ~ 60kDa
• NCBI Official Full Name: 60 kDa SS-A/Ro ribonucleoprotein isoform 1
• NCBI Official Synonym Full Names: Ro60, Y RNA binding protein
• NCBI Official Symbol: RO60
• NCBI Official Synonym Symbols: SSA2; RORNP; TROVE2
• NCBI Protein Information: 60 kDa SS-A/Ro ribonucleoprotein
• UniProt Protein Name: 60 kDa SS-A/Ro ribonucleoprotein
• Protein Family: 60 kDa SS-A/Ro ribonucleoprotein
• UniProt Gene Name: TROVE2
• UniProt Synonym Gene Names: RO60; SSA2; 60 kDa Ro protein; 60 kDa ribonucleoprotein Ro; RoRNP; SS-A
• UniProt Entry Name: RO60_HUMAN

Uniprot Description

SSA2: RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation. Belongs to the Ro 60 kDa family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: nucleoplasm; cytoplasm; ribonucleoprotein complex

Molecular Function: RNA binding; metal ion binding; U2 snRNA binding

Biological Process: transcription from RNA polymerase III promoter; immune system development; smoothened signaling pathway; response to UV

Disease: Heart Block, Congenital