Mouse ring finger protein 40 ELISA Kit | RNF40 elisa kit
Mouse E3 ubiquitin-protein ligase BRE1B, RNF40 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
RNF40: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with RB1 and WAC. Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine. Belongs to the BRE1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; Ubiquitin ligase; Ligase; EC 6.3.2.19; EC 6.3.2.-
Cellular Component: nucleoplasm; neuron projection; protein complex; membrane; nucleus; ubiquitin ligase complex
Molecular Function: protein homodimerization activity; mRNA 3'-UTR binding; zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; metal ion binding; ribosomal S6-glutamic acid ligase activity; ubiquitin-protein ligase activity; protein binding; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; ubiquitin protein ligase binding; protein complex binding; syntaxin-1 binding; coenzyme F420-0 gamma-glutamyl ligase activity; ligase activity
Biological Process: histone monoubiquitination; ubiquitin-dependent protein catabolic process; histone H2B ubiquitination; chromatin modification
Research Articles on RNF40
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Product Notes
The Mouse RNF40 rnf40 (Catalog #AAA9341041) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9341041 ELISA Kit recognizes Mouse RNF40. It is sometimes possible for the material contained within the vial of "ring finger protein 40, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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