E3 ubiquitin-protein ligase RNF146-A (RNF146A) Recombinant Protein | RNF146A recombinant protein

Recombinant Bovine E3 ubiquitin-protein ligase RNF146-A (RNF146A)

Purity

Greater or equal to 85% purity as determined by SDS-PAGE.

Synonyms

E3 ubiquitin-protein ligase RNF146-A (RNF146A); Recombinant Bovine E3 ubiquitin-protein ligase RNF146-A (RNF146A); RNF146A recombinant protein

Ordering
Cat. Num. AAA1137727 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE.

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Sequence Positions

1-346, full length protein

Sequence

MMAGCGETDHSINMLPTNRKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDRPTLLSPELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKSTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDANTVNLARESSADGADSVPAQSGASVQSSSVRPLTSVDGQLTSPATPSPDVGTSLEDSFAHLQLGGDSIAERSHRGEGEEEHESPSSGRVPAPDTSIEETESDASSDSEDVSALVAQHSLTQQRLLVPNPSQTVSDRSVAAGGIVSVRSRRPDGQCTVTEV

Sequence Length

346

Species

Bovine

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

NCBI GI #

334350815

NCBI GeneID

100336258

UniProt Accession #

E1B7X3

Molecular Weight

37,543 Da

NCBI Official Full Name

E3 ubiquitin-protein ligase RNF146-A

NCBI Official Symbol

LOC100336258

UniProt Protein Name

E3 ubiquitin-protein ligase RNF146-A

Protein Family

E3 ubiquitin-protein ligase

UniProt Gene Name

RNF146A

Uniprot Description

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination ().

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Product Notes

The RNF146A rnf146a (Catalog #AAA1137727) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-346, full length protein. The amino acid sequence is listed below: MMAGCGETDH SINMLPTNRK ANESCSNTAP SLTVPECAIC LQTCVHPVSL PCKHVFCYLC VKGASWLGKR CALCRQEIPE DFLDRPTLLS PELKAASRGN GEYAWYYEGR NGWWQYDERT SRELEDAFSK GKKSTEMLIA GFLYVADLEN MVQYRRNEHG RRRKIKRDII DIPKKGVAGL RLDCDANTVN LARESSADGA DSVPAQSGAS VQSSSVRPLT SVDGQLTSPA TPSPDVGTSL EDSFAHLQLG GDSIAERSHR GEGEEEHESP SSGRVPAPDT SIEETESDAS SDSEDVSALV AQHSLTQQRL LVPNPSQTVS DRSVAAGGIV SVRSRRPDGQ CTVTEV. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase RNF146-A (RNF146A), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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