Uniprot Description
E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome.
Product Notes
The rnf126-a rnf126-a (Catalog #
AAA1471071) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-312, Full length protein. The amino acid sequence is listed below: MAEALPKAGR YFCHSCTAEI TPRLPEYTCP RCDSGFIEEL PETSRNSENN SSNNSRTDQN RPSFENLESA QFTLPSGYGQ VTFGIFNEGL DFPIFGTSGP VEETRDGESR REHQSRQRYG ARQPRARLST RRAAGRNEGV PTLEGIIQQL VNGIIAPTAM SNLGVGPWGV LHSNPMDYAW GANGLDTIIT QLLNQFENTG PPPADNEKIQ ALPTIQITEE HVGSGLECPV CKEDYTVGEC VRQLPCNHLF HNDCIIPWLE QHDTCPVCRK SLSGQNTATN PPGLSEMTFS SSSTSSSSST SPTDENNSAN NS.
It is sometimes possible for the material contained within the vial of
"RING finger protein 126-A (rnf126-a), Recombinant Protein" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
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responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
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