Structure
DDR1 inhibitor 7rh, Inhibitor
DDR1 inhibitor 7rh
Purity
>98% (HPLC)
Synonyms
DDR1 inhibitor 7rh; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 12mg/mL (21.95mM), (18.3mM) (<1mg/mL refers to the product slightly soluble or insoluble)
Target
DDR
Receptor
DDR1; DDR2
Chemical Name
4-Ethyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)-3-(pyrazolo[1, 5-a]pyrimidin-6-ylethynyl)benzamide
SMILES
CCC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)CN3CCN(CC3)C)C#CC4=CN5C(=CC=N5)N=C4
Molecular Formula
C30H29F3N6O
CAS Number
1429617-90-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for DDR1 inhibitor 7rh, inhibitor
DDR1 inhibitor 7rh is a potent, selective, ATP-competitive, orally available Discoidin domain receptor 1 (DDR1) inhibitor with IC50 of 6.8nM in cell-free kinase assays; DDR1 inhibitor 7rh is significantly less potent in suppressing the kinase activities of DDR2 (IC50=101nM), Bcr-Abl (IC50=355nM), and c-Kit (IC50>10uM); inhibits DDR1-mediated signaling induced by soluble collagen (50ug/ml) in a concentration-dependent manner, inhibits activation of PYK2 and PEAK1, signaling proteins downstream of DDR1 in PANC-1 cells; induces significant decrease of total protein levels of DDR1 and Bcl-xL, causes a significant reduction in the level of MMP-2 in NSCLS cells; suppresses the growth of K562 human CML cells with IC50 of 38nM, A549, NCI-H23 and NCI-H460 human NSCLC cells with IC50 of 2.7, 2.1 and 3.0uM, respectively; abrogates collagen-induced DDR1 signaling in pancreatic tumor cells and consequently reduces colony formation and migration, exhibits striking efficacy in combination with chemotherapy in orthotopic xenografts and autochthonous pancreatic tumors.
Product Categories/Family for DDR1 inhibitor 7rh, inhibitor
References
1. Aguilera KY, et al. Mol Cancer Ther. 2017 Nov; 16 (11):2473-2485.
2. Gao M, et al. J Med Chem. 2013 Apr 25; 56 (8):3281-95.
2. Gao M, et al. J Med Chem. 2013 Apr 25; 56 (8):3281-95.
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Product Notes
The DDR1 inhibitor 7rh (Catalog #AAA3601812) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DDR1 inhibitor 7rh, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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