Rho-conotoxin TIA Recombinant Protein | Rho-TIA recombinant protein
Recombinant Conus tulipa Rho-conotoxin TIA
NCBI and Uniprot Product Information
Uniprot Description
Function: Reversibly inhibits alpha-1 adrenergic receptors (alpha-1B (ADRA1B) > alpha-1A (ADRA1A) = alpha-1D (ADRA1D)). Is a competitive antagonist of alpha-1A- and alpha-1D-adrenoceptors and a non-competitive antagonist of alpha-1B-adrenoceptors. Has no effect on alpha-2 adrenergic receptors. Potently inhibited contractions of vas deferens, spleen and aorta in response to noradrenaline. Ref.3 Ref.4 Ref.5
Subcellular location: Secreted.
Tissue specificity: Expressed by the venom duct.
Domain: The cysteine framework is I (CC-C-C).
Pharmaceutical use: Is under preclinical trial by Xenome.
Sequence similarities: Belongs to the conotoxin A superfamily.
Mass spectrometry: Molecular mass is 2390.15 Da from positions 1 - 19. Determined by ESI. Ref.2
Sequence caution: The sequence ADN79119.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
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Product Notes
The Rho-conotoxin TIA rho-tia (Catalog #AAA1179982) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 39-57. Full Length of Mature Protein. The amino acid sequence is listed below: FNWRCCLIPA CRRNHKKFC. It is sometimes possible for the material contained within the vial of "Rho-conotoxin TIA, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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