Adipose Tissue-Specific Secretory Factor Recombinant Protein | RETN recombinant protein

Recombinant Human Adipose Tissue-Specific Secretory Factor Protein

Cat. Num. AAA2556618

• Gene Names: RETN; ADSF; RSTN; XCP1; FIZZ3; RETN1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Adipose Tissue-Specific Secretory Factor; Recombinant Human Adipose Tissue-Specific Secretory Factor Protein; Resistin; Adipose tissue-specific secretory factor; Cysteine-rich secreted protein FIZZ3; C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 2; FIZZ3; HXCP1; RSTN; RETN; RETN recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM Acetic acid, pH 3.0.
• Sequence Length: 108

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Lys19-Pro108
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

SDS-Page

Related Product Information for RETN recombinant protein

Protein Construction: Recombinant Human Adipose tissue-specific secretory factor is produced by our E Coli expression system and the target gene encoding Lys19-Pro108 is expressed with a 6His tag at the C-terminus.

Background: Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus (T2DM). Resistin has been shown to cause "high levels of 'bad' cholesterol (low-density lipoprotein or LDL), increasing the risk of heart disease, resistin increases the production of LDL in human liver cells and also degrades LDL receptors in the liver. Potentially links obesity to diabetes.

NCBI and Uniprot Product Information

• NCBI GI #: 9966777
• NCBI GeneID: 56729
• NCBI Accession #: NP_065148.1
• NCBI GenBank Nucleotide #: NM_020415.4
• UniProt Accession #: Q9HD89; Q540D9; Q76B53; D6W649
• Molecular Weight: Molecular Mass: 10.6kDa; Actual Protein Molecular Mass: 10-14kDa
• NCBI Official Full Name: resistin
• NCBI Official Synonym Full Names: resistin
• NCBI Official Symbol: RETN
• NCBI Official Synonym Symbols: ADSF; RSTN; XCP1; FIZZ3; RETN1
• NCBI Protein Information: resistin
• UniProt Protein Name: Resistin
• Protein Family: Resistin
• UniProt Gene Name: RETN
• UniProt Synonym Gene Names: FIZZ3; HXCP1; RSTN; ADSF

NCBI Description

This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

Uniprot Description

Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (). Potentially links obesity to diabetes (). Promotes chemotaxis in myeloid cells (PubMed:15064728).