Human RalBP1-associated Eps domain-containing protein 2 ELISA Kit | REPS2 elisa kit

Human RalBP1-associated Eps domain-containing protein 2 ELISA Kit

Cat. Num. AAA762136

• Gene Names: REPS2; POB1
• Reactivity: Human
• Synonyms: RalBP1-associated Eps domain-containing protein 2; Human RalBP1-associated Eps domain-containing protein 2 ELISA Kit; REPS2/Partner of RalBP1/RalBP1-interacting protein 2/REPS2/POB1; REPS2 elisa kit

• Reactivity: Human
• Sequence Length: 659

• Samples: Serum, plasma and other biological fluids.
• Assay Type: Sandwich ELISA, Double Antibody
• Detection Range: 0.312-20ng/ml
• Sensitivity: 0.188ng/ml
• Preparation and Storage: Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).

Typical Standard Curve

NCBI and Uniprot Product Information

• NCBI GI #: 125625322
• NCBI GeneID: 9185
• NCBI Accession #: NP_001074444.1
• NCBI GenBank Nucleotide #: NM_001080975.1
• Molecular Weight: 71,405 Da
• NCBI Official Full Name: ralBP1-associated Eps domain-containing protein 2 isoform 2
• NCBI Official Synonym Full Names: RALBP1 associated Eps domain containing 2
• NCBI Official Symbol: REPS2
• NCBI Official Synonym Symbols: POB1
• NCBI Protein Information: ralBP1-associated Eps domain-containing protein 2
• UniProt Protein Name: RalBP1-associated Eps domain-containing protein 2
• Protein Family: RalBP1-associated Eps domain-containing protein
• UniProt Gene Name: REPS2
• UniProt Synonym Gene Names: POB1
• UniProt Entry Name: REPS2_HUMAN

NCBI Description

The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

REPS2: an adaptor protein involved in growth factor signaling through its influence on the Ral, a small G protein that regulates endocytosis of EGF and insulin receptors. Interacts with DDEF1, paxillin, RALBP1 and GRB2. Binding to RALBP1 does not affect the Ral-binding activity of the latter. Forms a ternary complex with activated Ral and RALBP1. Binds epsin 1. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. EGF receptor internalization and signalling is inhibited by increased expression of REPS2. EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter protein such as GRB2. Two alternatively spliced isoforms have been described. Isoform 2 is down-regulated during progression of prostate cancer.

Protein type: G protein regulator, misc.; Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: cytoplasm

Molecular Function: calcium ion binding; protein binding

Biological Process: epidermal growth factor receptor signaling pathway; protein complex assembly