Western Blot (WB)
(Western blot analysis REPS2 using COLO205 whole cell lysates)
Rabbit anti-Human, Mouse REPS2 Polyclonal Antibody | anti-REPS2 antibody
REPS2 Antibody
Western Blot (WB)
(Western blot analysis REPS2 using COLO205 whole cell lysates)
Western Blot (WB)
(Western blot analysis REPS2 using COLO205 whole cell lysates)
NCBI and Uniprot Product Information
NCBI Description
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
REPS2: an adaptor protein involved in growth factor signaling through its influence on the Ral, a small G protein that regulates endocytosis of EGF and insulin receptors. Interacts with DDEF1, paxillin, RALBP1 and GRB2. Binding to RALBP1 does not affect the Ral-binding activity of the latter. Forms a ternary complex with activated Ral and RALBP1. Binds epsin 1. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. EGF receptor internalization and signalling is inhibited by increased expression of REPS2. EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter protein such as GRB2. Two alternatively spliced isoforms have been described. Isoform 2 is down-regulated during progression of prostate cancer.
Protein type: Adaptor/scaffold; G protein regulator, misc.
Chromosomal Location of Human Ortholog: Xp22.2
Molecular Function: protein binding
Biological Process: epidermal growth factor receptor signaling pathway; protein complex assembly
Research Articles on REPS2
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Product Notes
The REPS2 reps2 (Catalog #AAA9419564) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The REPS2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's REPS2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:1000-3000. Researchers should empirically determine the suitability of the REPS2 reps2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "REPS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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