Protein Tyrosine Phosphatase, Receptor Type, G Active Protein | PTPRG active protein

Protein Tyrosine Phosphatase, Receptor Type, G (801-1147), catalytic domain, Recombinant, Human (RPTPg)

Cat. Num. AAA635794

• Gene Names: PTPRG; PTPG; HPTPG; RPTPG; R-PTP-GAMMA
• Reactivity: Human
• Purity: >95% by SDS-PAGE.
• Synonyms: Protein Tyrosine Phosphatase; Receptor Type; G; G (801-1147); catalytic domain; Recombinant; Human (RPTPg); PTPRG active protein

• Host: Recombinant, Human from E Coli
• Reactivity: Human
• Purity/Purification: >95% by SDS-PAGE.
• Form/Format: 25 mM Tris-HCl, pH 8.0, 75mM sodium chloride, 0.05% Tween-20, 50% glycerol, 2mM EDTA, 3mM DTT.

• Application Notes: useful for the study of enzyme kinetics, regulation, and to dephosphorylate target substrates.
• Specific Activity: 10 U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30 degree C
• Assay Buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50mM pNPP.
• Location: 3p21-p14
• Preparation and Storage: -70 degree C; Stability: 6 months at -20 degree C

Related Product Information for PTPRG active protein

Catalytic domain, (a.a. 801-1147), MW=39.6kD, expressed in an E. coli expression system.

Product Categories/Family for PTPRG active protein

Molecular Biology; MB-Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 187955007
• NCBI GeneID: 5793
• UniProt Accession #: P23470; Q15623; Q59EE0; Q68DU5; B2RU12
• Molecular Weight: 162,003 Da
• NCBI Official Full Name: Protein tyrosine phosphatase, receptor type, G
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type, G
• NCBI Official Symbol: PTPRG
• NCBI Official Synonym Symbols: PTPG; HPTPG; RPTPG; R-PTP-GAMMA
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase gamma; H_RG317H01.1; protein tyrosine phosphatase gamma; protein-tyrosine phosphatase gamma; receptor tyrosine phosphatase gamma; receptor-type protein phosphatase gamma; receptor type protein tyrosine phosphatase gamma; protein tyrosine phosphatase, receptor type, gamma polypeptide
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase gamma
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: PTPRG
• UniProt Synonym Gene Names: PTPG; Protein-tyrosine phosphatase gamma; R-PTP-gamma
• UniProt Entry Name: PTPRG_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]

Uniprot Description

PTPRG: Possesses tyrosine phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.3.48; Receptor protein phosphatase, tyrosine; Phosphatase

Chromosomal Location of Human Ortholog: 3p21-p14

Cellular Component: extracellular space; integral to plasma membrane

Molecular Function: identical protein binding; protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: brain development; transmembrane receptor protein tyrosine kinase signaling pathway