RCN2 recombinant protein

Recombinant Human RCN2 (C-6His)

Cat. Num. AAA2569218

• Gene Names: RCN2; E6BP; ERC55; ERC-55; TCBP49
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: RCN2; Recombinant Human RCN2 (C-6His); Reticulocalbin-2; E6BP; ERC55; RCN2 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Supplied as a 0.2um filtered solution of 20mM Tris-HCl, 10% Glycerol, 1mM DTT, pH8.0.
• Sequence: Gly23-Leu317

• Species: Human
• Tag: C-6His
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Human Reticulocalbin-2 is produced by our Mammalian expression system and the target gene encoding Gly23-Leu317 is expressed with a 6His tag at the C-terminus.
• Preparation and Storage: Store at < -20 degree C, stable for 6 months. Please minimize freeze-thaw cycles.; This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20 degree C.

SDS-Page

Related Product Information for RCN2 recombinant protein

Reticulocalbin-2 (RCN2, also named as ERC-55), is a 55-kDa Ca2+-binding protein containing six EF-hands, which was identified to be localized in endoplasmic reticulum. RCN2 is belonging to Reticulocalbin (RCN) family, the family members could play oncogenic roles in human malignancies and facilitate tumor cell proliferation and metastasis. Recently, studies on RCN2 functions mainly focused on its role in differentiation and endocrine regulation in mouse. Another study has suggested that RCN2 could be a potential tumor-associated antigen for mammary cancer immunological prevention. Up to now, the experimental evidence uncovering the role of RCN2 in cancer is very limited.

NCBI and Uniprot Product Information

• NCBI GI #: 2493460
• NCBI GeneID: 5955
• UniProt Accession #: Q14257; Q53XN8; A8MTG6; F8WCY5
• Molecular Weight: 317
• NCBI Official Full Name: Reticulocalbin-2
• NCBI Official Synonym Full Names: reticulocalbin 2, EF-hand calcium binding domain
• NCBI Official Symbol: RCN2
• NCBI Official Synonym Symbols: E6BP; ERC55; ERC-55; TCBP49
• NCBI Protein Information: reticulocalbin-2; E6-binding protein; calcium-binding protein ERC-55; reticulocalbin 2, EF-hand calcium binding domain (endoplasmic reticulum calcium-binding protein, 55kD)
• UniProt Protein Name: Reticulocalbin-2
• Protein Family: Reticulocalbin
• UniProt Gene Name: RCN2
• UniProt Synonym Gene Names: ERC55; E6BP
• UniProt Entry Name: RCN2_HUMAN

NCBI Description

The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]

Uniprot Description

RCN2: Not known. Binds calcium. Belongs to the CREC family.

Protein type: Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum; nucleolus

Molecular Function: protein binding; calcium ion binding