Human retina and anterior neural fold homeobox ELISA Kit | RAX elisa kit
Human Retinal homeobox protein Rx, RAX ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a homeobox-containing transcription factor that functions in eye development. The gene is expressed early in the eye primordia, and is required for retinal cell fate determination and also regulates stem cell proliferation. Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia, and coloboma.[provided by RefSeq, Oct 2009]
Uniprot Description
RAX: Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter. Defects in RAX are the cause of microphthalmia isolated type 3 (MCOP3). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present. Belongs to the paired homeobox family. Bicoid subfamily.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 18q21.32
Cellular Component: nucleus
Biological Process: limb development; hypothalamus development; camera-type eye development; visual perception; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; pattern specification process
Disease: Microphthalmia, Isolated 3
Research Articles on RAX
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Product Notes
The Human RAX rax (Catalog #AAA9324179) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324179 ELISA Kit recognizes Human RAX. It is sometimes possible for the material contained within the vial of "retina and anterior neural fold homeobox, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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