Rat Transthyretin (TTR) ELISA Kit | TTR elisa kit
Rat Transthyretin (TTR) Mini Samples ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
binds thyroxine (T4) and 3,5,3' triiodothyronine (T3); plays a role in thyroid hormone transport in serum [RGD, Feb 2006]
Uniprot Description
TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 18p12
Cellular Component: extracellular space; protein complex
Molecular Function: hormone binding; identical protein binding; protein heterodimerization activity
Biological Process: purine base metabolic process; retinol metabolic process; thyroid hormone metabolic process
Research Articles on TTR
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Product Notes
The Rat TTR ttr (Catalog #AAA2087558) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2087558 ELISA Kit recognizes Rat TTR. It is sometimes possible for the material contained within the vial of "Transthyretin (TTR), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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