Rat Regulator of G-Protein Signaling 7-Binding Protein (RGS7BP) ELISA Kit | RGS7BP elisa kit

Rat Regulator of G-Protein Signaling 7-Binding Protein (RGS7BP) ELISA Kit

Cat. Num. AAA9355929

• Gene Names: RGS7BP; R7BP
• Reactivity: Rat
• Synonyms: Regulator of G-Protein Signaling 7-Binding Protein (RGS7BP); Rat Regulator of G-Protein Signaling 7-Binding Protein (RGS7BP) ELISA Kit; RGS7BP elisa kit

• Reactivity: Rat

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 429325224
• NCBI GeneID: 401190
• NCBI Accession #: NP_001258820.1
• NCBI GenBank Nucleotide #: NM_001271891.1
• Molecular Weight: 28,962 Da
• NCBI Official Full Name: regulator of G-protein signaling 7-binding protein isoform 3
• NCBI Official Synonym Full Names: regulator of G-protein signaling 7 binding protein
• NCBI Official Symbol: RGS7BP
• NCBI Official Synonym Symbols: R7BP
• NCBI Protein Information: regulator of G-protein signaling 7-binding protein
• UniProt Protein Name: Regulator of G-protein signaling 7-binding protein
• Protein Family: Regulator of G-protein signaling 7-binding protein
• UniProt Gene Name: RGS7BP
• UniProt Synonym Gene Names: R7BP
• UniProt Entry Name: R7BP_HUMAN

NCBI Description

This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

Uniprot Description

RGS7BP: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. Belongs to the RGS7BP/RGS9BP family.

Chromosomal Location of Human Ortholog: 5q12.3

Cellular Component: cytoplasm; nucleus; plasma membrane

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of signal transduction