Rat Platelet Derived Growth Factor Receptor Alpha (PDGFRa) ELISA Kit | PDGFRa elisa kit

Rat Platelet Derived Growth Factor Receptor Alpha (PDGFRa) ELISA Kit

Cat. Num. AAA453424

• Gene Names: Pdgfra; APDGFR; PDGFACE
• Reactivity: Rat
• Synonyms: Platelet Derived Growth Factor Receptor Alpha (PDGFRa); Rat Platelet Derived Growth Factor Receptor Alpha (PDGFRa) ELISA Kit; CD140a; PDGFR2; Rhe-PDGFRA; CD140 antigen-like family member A; Platelet-derived growth factor receptor 2; Alpha-type platelet-derived growth factor receptor; PDGFRa elisa kit

• Reactivity: Rat
• Sequence Length: 1088

• Samples: Tissue homogenates, cell lysates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.156-10ng/mL
• Sensitivity: 0.054ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 158186636
• NCBI GeneID: 25267
• NCBI Accession #: NP_036934.1
• NCBI GenBank Nucleotide #: NM_012802.1
• UniProt Accession #: P20786
• Molecular Weight: 122,642 Da
• NCBI Official Full Name: platelet-derived growth factor receptor alpha
• NCBI Official Synonym Full Names: platelet derived growth factor receptor alpha
• NCBI Official Symbol: Pdgfra
• NCBI Official Synonym Symbols: APDGFR; PDGFACE
• NCBI Protein Information: platelet-derived growth factor receptor alpha
• UniProt Protein Name: Platelet-derived growth factor receptor alpha
• Protein Family: Platelet-derived growth factor receptor
• UniProt Gene Name: Pdgfra
• UniProt Synonym Gene Names: PDGF-R-alpha; PDGFR-alpha

NCBI Description

acts as a receptor tyrosine kinase for PDGF; may play a role in glial cell generation [RGD, Feb 2006]

Uniprot Description

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor ().