Rat natural resistance-associated macrophage protein 2 (NRAMP2) ELISA Kit | NRAMP2 elisa kit
Rat natural resistance-associated macrophage protein 2 (NRAMP2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
mediates proton coupled transport of broad range of divalent metal ions; may play a role in intestinal iron absorption [RGD, Feb 2006]
Uniprot Description
Function: Important in metal transport, in particular iron. Can also transport zinc, manganese, cobalt, cadmium, copper, nickel and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. Ref.1
Subunit structure: Forms a complex with NDFIP1 and NEDD4L, in cortical neurons, in response to iron and colbalt exposure; this interaction leads to ubiquitination by NEDD4L and proteasome-dependent degradation. Interacts with NDFIP2
By similarity.
Subcellular location: Endosome membrane; Multi-pass membrane protein
By similarity.
Tissue specificity: Ubiquitous.
Post-translational modification: Ubiquitinated by WWP2
By similarity.
Involvement in disease: Defects in Slc11a2 are the cause of microcytic anemia (Belgrade or b). Homozygous b/b rats have hypochromic microcytic anemia due to severe defects in intestinal iron absorption and erythroid iron utilization.
Sequence similarities: Belongs to the NRAMP family.
Research Articles on NRAMP2
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Product Notes
The Rat NRAMP2 slc11a2 (Catalog #AAA9336431) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336431 ELISA Kit recognizes Rat NRAMP2. It is sometimes possible for the material contained within the vial of "natural resistance-associated macrophage protein 2 (NRAMP2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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